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Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications
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SYSNO ASEP 0523852 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications Tvůrce(i) Zárubová, Jana (FGU-C) RID, ORCID
Hasani-Sadrabadi, M. M. (US)
Bačáková, Lucie (FGU-C) RID, ORCID
Li, S. (US)Číslo článku 158 Zdroj.dok. Micromachines. - : MDPI
Roč. 11, č. 2 (2020)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova chronic wounds ; angiogenesis ; antibacterial properties ; drug delivery ; microfluidics ; nanoparticles ; microparticles Vědní obor RIV EI - Biotechnologie a bionika Obor OECD Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction) CEP LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000520181500047 EID SCOPUS 85081159618 DOI 10.3390/mi11020158 Anotace Here, we developed a combinatorial delivery platform for chronic wound healing applications. A microfluidic system was utilized to form a series of biopolymer-based microparticles with enhanced affinity to encapsulate and deliver vascular endothelial growth factor (VEGF). Presence of heparin into the structure can significantly increase the encapsulation efficiency up to 95% and lower the release rate of encapsulated VEGF. Our in vitro results demonstrated that sustained release of VEGF from microparticles can promote capillary network formation and sprouting of endothelial cells in 2D and 3D microenvironments. These engineered microparticles can also encapsulate antibiotic-loaded nanoparticles to offer a dual delivery system able to fight bacterial infection while promoting angiogenesis. We believe this highly tunable drug delivery platform can be used alone or in combination with other wound care products to improve the wound healing process and promote tissue regeneration. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://doi.org/10.3390/mi11020158
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