Počet záznamů: 1
Downregulation of respiratory complex I mediates major signalling changes triggered by TOR activation
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SYSNO ASEP 0523004 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Downregulation of respiratory complex I mediates major signalling changes triggered by TOR activation Tvůrce(i) Perez-Gomez, Raquel (BC-A) RID, ORCID
Magnin, Valentina (BC-A)
Mihajlović, Zorana (BC-A)
Slaninová, Věra (BC-A)
Krejčí, Alena (BC-A) RID, ORCIDCelkový počet autorů 5 Číslo článku 4401 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 10, č. 1 (2020)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova mitochondria dysfunction ; complex I ; TOR signalling Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GA17-17529S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 000563372900003 EID SCOPUS 85081607911 DOI 10.1038/s41598-020-61244-3 Anotace Mitochondrial dysfunctions belong amongst the most common metabolic diseases but the signalling networks that lead to the manifestation of a disease phenotype are often not well understood. We identified the subunits of respiratory complex I, III and IV as mediators of major signalling changes during Drosophila wing disc development. Their downregulation in larval wing disc leads to robust stimulation of TOR activity, which in turn orchestrates a complex downstream signalling network. Specifically, after downregulation of the complex I subunit ND-49 (mammalian NDUFS2), TOR activates JNK to induce cell death and ROS production essential for the stimulation of compensatory apoptosis-induced proliferation within the tissue. Additionally, TOR upregulates Notch and JAK/STAT signalling and it directs glycolytic switch of the target tissue. Our results highlight the central role of TOR signalling in mediating the complex response to mitochondrial respiratory dysfunction and they provide a rationale why the disease symptoms associated with respiratory dysfunctions are often alleviated by mTOR inhibitors. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2021 Elektronická adresa https://www.nature.com/articles/s41598-020-61244-3.pdf
Počet záznamů: 1