Počet záznamů: 1
Curcumin- and fish oil-loaded spongosome and cubosome nanoparticles with neuroprotective potential against H.sub.2./sub.O.sub.2./sub.-induced oxidative stress in differentiated human SH-SY5Y cells
- 1.
SYSNO ASEP 0521339 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Curcumin- and fish oil-loaded spongosome and cubosome nanoparticles with neuroprotective potential against H2O2-induced oxidative stress in differentiated human SH-SY5Y cells Tvůrce(i) Rakotoarisoa, M. (FR)
Angelov, Borislav (FZU-D) ORCID
Garamus, V.M. (DE)
Angelova, A. (FR)Celkový počet autorů 4 Zdroj.dok. ACS Omega. - : American Chemical Society - ISSN 2470-1343
Roč. 4, č. 2 (2019), s. 3061-3073Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova liquid-crystalline phases ; solid lipid nanoparticles ; blood-brain-barrier ; x-ray-scattering ; alzheimers-disease ; drug-delivery ; neurodegenerative diseases Vědní obor RIV BL - Fyzika plazmatu a výboje v plynech Obor OECD Fluids and plasma physics (including surface physics) CEP LQ1606 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora FZU-D - RVO:68378271 UT WOS 000460237300064 EID SCOPUS 85061567404 DOI 10.1021/acsomega.8b03101 Anotace Many phytochemical antioxidant compounds, including curcumin (CU), are water-insoluble and thus require delivery carriers in order to increase their bioavailability for in vivo applications. Oxidative stress-related apoptosis is a common cause for the neuronal loss in the progression of neurodegenerative diseases. Lipid nanoparticles (NPs) with internal self-assembled liquid crystalline structures present strong interest as safe drug delivery systems for neuronal regeneration through combination therapies. Here, we report spongosome and cubosome lipid NPs, which co-encapsulate CU and fish oil (FO), rich in omega-3 polyunsaturated fatty acids. The performed structural investigation by synchrotron small-angle X-ray scattering evidenced the liquid crystalline organization of the self-assembled NPs. The encapsulation efficiency for CU in the lipid nanocarriers was found to be higher as compared to that reported for polymer-based carriers. Pracoviště Fyzikální ústav Kontakt Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Rok sběru 2020 Elektronická adresa http://hdl.handle.net/11104/0305968
Počet záznamů: 1