Počet záznamů: 1
Message in a vesicle trans-kingdom intercommunication at the vector-host interface
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SYSNO ASEP 0518848 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Message in a vesicle trans-kingdom intercommunication at the vector-host interface Tvůrce(i) Chávez, A.S.O. (US)
O'Neal, A.J. (US)
Santambrogio, L. (US)
Kotsyfakis, Michalis (BC-A) RID, ORCID
Pedra, J. H. F. (US)Celkový počet autorů 5 Číslo článku jcs224212 Zdroj.dok. Journal of Cell Science. - : Company of Biologists - ISSN 0021-9533
Roč. 132, č. 6 (2019)Poč.str. 11 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova extracellular vesicles ; trypanosoma-cruzi ; proteomic analysis ; protein ; exosomes ; parasite ; tick ; leishmania ; secretion ; membrane ; Extracellular vesicle ; Arthropod-borne disease ; Cell communication ; Immunomodulation ; Microbial transmission Vědní obor RIV EA - Morfologické obory a cytologie Obor OECD Cell biology Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 000462864300011 EID SCOPUS 85063290362 DOI 10.1242/jcs.224212 Anotace Vector-borne diseases cause over 700,000 deaths annually and represent 17% of all infectious illnesses worldwide. This public health menace highlights the importance of understanding how arthropod vectors, microbes and their mammalian hosts interact. Currently, an emphasis of the scientific enterprise is at the vector-host interface where human pathogens are acquired and transmitted. At this spatial junction, arthropod effector molecules are secreted, enabling microbial pathogenesis and disease. Extracellular vesicles manipulate signaling networks by carrying proteins, lipids, carbohydrates and regulatory nucleic acids. Therefore, they are well positioned to aid in cell-to-cell communication and mediate molecular interactions. This Review briefly discusses exosome and microvesicle biogenesis, their cargo, and the role that nanovesicles play during pathogen spread, host colonization and disease pathogenesis. We then focus on the role of extracellular vesicles in dictating microbial pathogenesis and host immunity during transmission of vector-borne pathogens. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2020 Elektronická adresa https://jcs.biologists.org/content/joces/132/6/jcs224212.full.pdf
Počet záznamů: 1