Počet záznamů: 1

Separation of racemic compound by nanofibrous composite membranes with chiral selector.

SYSNO ASEP	0517428
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Separation of racemic compound by nanofibrous composite membranes with chiral selector.
Tvůrce(i)	Gaálová, Jana (UCHP-M)_{RID, SAI, ORCID} Yalcinkaya, F. (CZ) Cuřínová, Petra (UCHP-M)_{RID, SAI, ORCID} Kohout, M. (CZ) Yalcinkaya, B. (CZ) Koštejn, Martin (UCHP-M)_{RID, SAI, ORCID} Jirsák, J. (CZ) Stibor, I. (CZ) Bara, J. E. (US) Van der Bruggen, B. (BE) Izák, Pavel (UCHP-M)_{RID, ORCID, SAI}
Číslo článku	117728
Zdroj.dok.	Journal of Membrane Science. - : Elsevier - ISSN 0376-7388 Roč. 596, FEB 15 (2020)
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	chiral resolution ; composite membrane ; pertraction
Vědní obor RIV	CI - Průmyslová chemie a chemické inženýrství
Obor OECD	Chemical process engineering
CEP	GA17-00089S GA ČR - Grantová agentura ČR
Způsob publikování	Omezený přístup
Institucionální podpora	UCHP-M - RVO:67985858
UT WOS	000512677400041
EID SCOPUS	85076248128
DOI	10.1016/j.memsci.2019.117728
Anotace	A series of unique composite membranes formed from a nanoµ fibrous material with different amounts of a chiral selector was used for separation of chiral drugs. The membrane performances were demonstrated through sorption tests, wherein they were soaked in an aqueous solution of racemic D,L-tryptophan (a model chiral drug). The changes in concentration of both enantiomers over time were monitored by HPLC analysis. During 100 days, a blank membrane (without the chiral selector) exhibited no sorption activity. The membranes containing the selector had no influence on the amount of d-enantiomer, while the l-enantiomer was preferentially adsorbed on each membrane. The intensity of the sorption was found to be a direct function of the amount of the selector contained in a particular membrane. The separation of the same model chiral compound was further studied in diffusion cells by pertraction. The preferential sorption of l-tryptophan in the feed underlined the crucial importance of the selector in an active layer in view of chiral recognition of enantiomers. Due to the exclusive membrane material, the retention of l-tryptophan in the membrane materials did not block the passage of d-enantiomer into the permeate at any point during the experiment. Moreover, the nanomaterial in the active layer assured the distribution of the selector to the point that only 50% of (S, S)-1,2-diaminocyclohexane in one part of the active layer was sufficient to achieve 99% of enantioselectivity. The membranes – fresh and used – were analysed by Fourier-transform infrared (FTIR) spectroscopy and characterized by scanning electron microscopy (SEM) confirming the stability of the tested membranes. To complete the study, the role of the polyamide active layer in chiral recognition of tryptophan enantiomers was proposed.
Pracoviště	Ústav chemických procesů
Kontakt	Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
Rok sběru	2021
Elektronická adresa	http://hdl.handle.net/11104/0303718

Počet záznamů: 1