Počet záznamů: 1
Neuronal Migration Generates New Populations of Neurons That Develop Unique Connections, Physiological Properties and Pathologies
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SYSNO ASEP 0511440 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Neuronal Migration Generates New Populations of Neurons That Develop Unique Connections, Physiological Properties and Pathologies Tvůrce(i) Fritzsch, B. (US)
Elliott, K. L. (US)
Pavlínková, Gabriela (BTO-N) RID, ORCID
Duncan, J. S. (US)
Hansen, M. R. (US)
Kersigo, J. M. (US)Celkový počet autorů 6 Číslo článku 59 Zdroj.dok. Frontiers in Cell and Developmental Biology. - : Frontiers Research Foundation - ISSN 2296-634X
Roč. 7, APR 24 2019 (2019)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova ear sensory epithelia ; spiral ganglion ; oculomotor ; evolution Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP GA17-04719S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000467206100001 EID SCOPUS 85065138333 DOI 10.3389/fcell.2019.00059 Anotace Central nervous system neurons become postmitotic when radial glia cells divide to form neuroblasts. Neuroblasts may migrate away from the ventricle radially along glia fibers, in various directions or even across the midline. We present four cases of unusual migration that are variably connected to either pathology or formation of new populations of neurons with new connectivities. One of the best-known cases of radial migration involves granule cells that migrate from the external granule cell layer along radial Bergman glia fibers to become mature internal granule cells. In various medulloblastoma cases this migration does not occur and transforms the external granule cell layer into a rapidly growing tumor. Among the ocular motor neurons is one unique population that undergoes a contralateral migration and uniquely innervates the superior rectus and levator palpebrae muscles. In humans, a mutation of a single gene ubiquitously expressed in all cells, induces innervation defects only in this unique motor neuron population, leading to inability to elevate eyes or upper eyelids. One of the bestknown cases for longitudinal migration is the facial branchial motor (FBM) neurons and the overlapping inner ear efferent population. We describe here molecular cues that are needed for the caudal migration of FBM to segregate these motor neurons from the differently migrating inner ear efferent population. Finally, we describe unusual migration of inner ear spiral ganglion neurons that result in aberrant connections with disruption of frequency presentation. Combined, these data identify unique migratory properties of various neuronal populations that allow them to adopt new connections but also sets them up for unique pathologies. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2020 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fcell.2019.00059/full
Počet záznamů: 1