Počet záznamů: 1
Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents
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SYSNO ASEP 0509934 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents Tvůrce(i) Šťastný, Martin (UACH-T) SAI, RID
Štengl, Václav (UACH-T) RID, ORCID, SAI
Štenglová Netíková, I. R. (CZ)
Šrámová Slušná, Michaela (UACH-T) SAI
Janoš, P. (CZ)Celkový počet autorů 5 Číslo článku 0223117 Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 14, č. 10 (2019)Poč.str. 25 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova titanium dioxide nanoparticle ; anthracyclines ; sodium hydroxide Vědní obor RIV CA - Anorganická chemie Obor OECD Inorganic and nuclear chemistry Způsob publikování Open access Institucionální podpora UACH-T - RVO:61388980 UT WOS 000530285000001 EID SCOPUS 85073157915 DOI 10.1371/journal.pone.0223117 Anotace Anthracyclines are a class of pharmaceuticals used in cancer treatment have the potential to negatively impact the environment. To study the possibilities of anthracyclines (represented by pirarubicin and valrubicin) removal, chemical inactivation using NaOH (0.01 M) and NaClO (5%) as decontamination agents and adsorption to powdered nanocrystalline titanium dioxide (TiO2) were compared. The titanium dioxide (TiO2) nanoparticles were prepared via homogeneous precipitation of an aqueous solution of titanium (IV) oxy-sulfate (TiOSO4) at different amount (5-120 g) with urea. The as-prepared TiO2 samples were characterized by XRD, HRSEM and nitrogen physisorption. The adsorption process of anthracycline cytostatics was determined followed by high-performance liquid chromatography coupled with mass spectrometry (LC-MS) and an in-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) technique. It was found that NaClO decomposes anthracyclines to form various transformation products (TPs). No TPs were identified after the reaction of valrubicin with a NaOH solution as well as in the presence of TiO2 nanoparticles. The best degree of removal, 100% of pirarubicin and 85% of valrubicin, has been achieved in a sample with 120 grams of TiOSO4 (TIT120) and TiO2 with 60 grams (TIT60), respectively. Pracoviště Ústav anorganické chemie Kontakt Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Rok sběru 2020 Elektronická adresa http://hdl.handle.net/11104/0300522
Počet záznamů: 1