Počet záznamů: 1

Telomerase activity is upregulated in the fat bodies of pre-diapause bumblebee queens (Bombus terrestris)

SYSNO ASEP	0509046
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Telomerase activity is upregulated in the fat bodies of pre-diapause bumblebee queens (Bombus terrestris)
Tvůrce(i)	Koubová, Justina (BC-A)_ORCID Jehlík, Tomáš (BC-A)_ORCID Kodrík, Dalibor (BC-A)_{RID, ORCID} Sábová, Michala (BC-A)_{RID, ORCID} Šima, P. (SK) Sehadová, Hana (BC-A)_{RID, ORCID} Závodská, Radka (BC-A)_{RID, ORCID} Čapková Frydrychová, Radmila (BC-A)_{RID, ORCID}
Celkový počet autorů	8
Číslo článku	103241
Zdroj.dok.	Insect Biochemistry and Molecular Biology. - : Elsevier - ISSN 0965-1748 Roč. 115, DEC 01 (2019)
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	telemerase ; telomeres ; ageing
Vědní obor RIV	CE - Biochemie
Obor OECD	Biochemistry and molecular biology
CEP	GA18-21200S GA ČR - Grantová agentura ČR
	LTAUSA17116 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Způsob publikování	Omezený přístup
Institucionální podpora	BC-A - RVO:60077344
UT WOS	000500048500002
EID SCOPUS	85072401329
DOI	10.1016/j.ibmb.2019.103241
Anotace	The attrition of telomeres, the ends of eukaryote chromosomes, and activity of telomerase, the enzyme that restores telomere length, play a role in the ageing process and act as indicators of biological age. A notable feature of advanced eusocial insects is the longevity of reproductive individuals (queens and kings) compared to those from non-reproductive castes (workers and soldiers) within a given species, with a proposed link towards upregulation of telomerase activity in the somatic tissues of reproductive individuals. Given this, eusocial insects provide excellent model systems for research into ageing. We tested telomerase activity and measured telomere length in Bombus terrestris, which is a primitively eusocial insect species with several distinct features compared to advanced social insects. In somatic tissues, telomerase activity was upregulated only in the fat bodies of pre-diapause queens, and this upregulation was linked to heightened DNA synthesis. Telomere length was shorter in old queens compared to that in younger queens or workers. We speculate that (1) the upregulation of telomerase activity, together with DNA synthesis, is the essential step for intensifying metabolic activity in the fat body to build up a sufficient energy reserve prior to diapause, and that (2) the lifespan differences between B. terrestris workers and queens are related to the long diapause period of the queen. A possible relationship between telomere length regulation and TOR, FOXO, and InR as cell signaling components, was tested.
Pracoviště	Biologické centrum (od r. 2006)
Kontakt	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Rok sběru	2020
Elektronická adresa	https://www.sciencedirect.com/science/article/pii/S0965174819303558?via%3Dihub

Počet záznamů: 1