Počet záznamů: 1
The mobility of mitochondria: Intercellular trafficking in health and disease
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SYSNO ASEP 0507981 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The mobility of mitochondria: Intercellular trafficking in health and disease Tvůrce(i) Berridge, M.V. (NZ)
Neužil, Jiří (BTO-N) RIDCelkový počet autorů 2 Zdroj.dok. Clinical and Experimental Pharmacology and Physiology. - : Wiley - ISSN 0305-1870
Roč. 44, DEC 2017 (2017), s. 15-20Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. AU - Austrálie Klíč. slova bioenergetics ; cancer ; intercellular mitochondrial trafficking ; disease Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Pharmacology and pharmacy CEP GAP301/10/1937 GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000418663800003 EID SCOPUS 85030033108 DOI 10.1111/1440-1681.12764 Anotace The view that genes are constrained within somatic cells is challenged by in vitro evidence, and more recently by in vivo studies which demonstrate that mitochondria with their mitochondrial DNA (mtDNA) payload not only can, but do move between cells in tumour models and in mouse models of tissue damage. Using mouse tumour cell models without mtDNA to reflect mtDNA damage, we have shown that these cells grow tumours only after acquiring mtDNA from cells in the local microenvironment resulting in respiration recovery, tumorigenesis and metastasis. Mitochondrial transfer between cells has also been demonstrated following ischaemia-induced injury in the heart and brain and in lung epithelium, and following lung inflammation. In vitro investigations suggest that stem cells may be mitochondrial donors. The ability of mitochondria to move between cells appears to be an evolutionarily-conserved phenomenon, relevant to diseases with compromised mitochondrial function including neurodegenerative, neuromuscular and cardiovascular diseases as well as cancer and ageing. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2020 Elektronická adresa https://onlinelibrary.wiley.com/doi/full/10.1111/1440-1681.12764
Počet záznamů: 1