Počet záznamů: 1
Extracellular biopolymers produced by Dictyosphaerium family - Chemical and immunomodulative properties
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SYSNO ASEP 0505098 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Extracellular biopolymers produced by Dictyosphaerium family - Chemical and immunomodulative properties Tvůrce(i) Halaj, M. (SK)
Paulovičová, E. (SK)
Paulovičová, L. (SK)
Jantová, S. (SK)
Cepák, Vladislav (BU-J) RID
Lukavský, Jaromír (BU-J) RID, ORCID
Capek, P. (SK)Celkový počet autorů 7 Zdroj.dok. International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130
Roč. 121, JAN 2019 (2019), s. 1254-1263Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Green microalgae ; Dictyosphaerium ; Extracellular biopolymers ; Immunomodulative effectivity Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP TE01020080 GA TA ČR - Technologická agentura ČR Způsob publikování Omezený přístup Institucionální podpora BU-J - RVO:67985939 UT WOS 000452346100140 EID SCOPUS 85055340432 DOI 10.1016/j.ijbiomac.2018.10.116 Anotace Many microalgal species produce a wide range of highly-value products which are interesting for biotechnological applications. Cultivation of microalgal species Dictyosphaerium pulchellum and Dictyosphaerium tetrachotomum, strains Růžicka and Fott resulted yields of 0.2, 0.7 and 1.8 g/L of extracellular biopolymers (EPSs), respectively. All biopolymers were shown to be anionic proteoglycans. The sugar composition analyses of all EPSs showed high contents of hexoses and the presence of partially methylated monosaccharide residues, i.e. hexoses, and deoxy hexoses. The dominant sugar component of all EPSs was found to be galactose. Extracellular microalgal biopolymers were subjected to immunobiological and immunotoxicological evaluation using murine melanoma cancer cells B16, murine fibroblast cell line NIH-3T3, murine macrophages cell line RAW 264.7 and skin construct EpiDerm™ (EPI-200). The EPSs exerted the antiproliferative effectivity treatment of EPS induced proinflammatory cytokines TNF-α, IL-6, IL-12, IL-1β and IL-17, also engaged in anti-cancer immunity. Immunotoxicological studies revealed their non-toxic character and safe application on EpiDerm™. Pracoviště Botanický ústav Kontakt Martina Bartošová, martina.bartosova@ibot.cas.cz, ibot@ibot.cas.cz, Tel.: 271 015 242 ; Marie Jakšová, marie.jaksova@ibot.cas.cz, Tel.: 384 721 156-8 Rok sběru 2020 Elektronická adresa http://hdl.handle.net/11104/0296634
Počet záznamů: 1