Počet záznamů: 1
Do different nuclei in a binucleated cardiomyocyte have different rates of nuclear protein import?
- 1.
SYSNO ASEP 0503879 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Do different nuclei in a binucleated cardiomyocyte have different rates of nuclear protein import? Tvůrce(i) Hlaváčková, Markéta (FGU-C) RID, ORCID
Kardami, E. (CA)
Fandrich, R. (CA)
Pierce, G. N. (CA)Zdroj.dok. Journal of Molecular and Cellular Cardiology. - : Elsevier - ISSN 0022-2828
Roč. 126, JAN (2019), s. 140-142Poč.str. 3 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova nucleus ; nucleocytoplasmic trafficking ; binuclear cell ; cardiomyocytes ; nuclear protein import Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000456637700014 EID SCOPUS 85057823653 DOI 10.1016/j.yjmcc.2018.08.030 Anotace The functional significance of having two nuclei in a cell is unknown. Having two stores of genetic material may be advantageous for cell growth. Nuclear protein import is at a critical juncture in the cell to modify cell growth. This study addressed the potential for differential nuclear protein import in two nuclei of the same cell. Isolated adult rat cardiomyocytes were microinjected with an exogenous fluorescent protein conjugated with nuclear localization amino acid sequences to facilitate nuclear import and its detection. Our results demonstrate the rate of nuclear protein import was not significantly different between the two nuclei in the same cell. These data demonstrate that the two nuclei are functionally similar in a binucleated cardiomyocyte, at least as far as nucleocytoplasmic transport is concerned. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2020 Elektronická adresa https://doi.org/10.1016/j.yjmcc.2018.08.030
Počet záznamů: 1