Počet záznamů: 1  

Muscle Cell and Tissue : Current Status of Research Field

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    SYSNO ASEP0499708
    Druh ASEPM - Kapitola v monografii
    Zařazení RIVC - Kapitola v knize
    NázevThe Role of Vascular Smooth Muscle Cells in the Physiology and Pathophysiology of Blood Vessels
    Tvůrce(i) Bačáková, Lucie (FGU-C) RID, ORCID
    Trávníčková, Martina (FGU-C) RID, ORCID, SAI
    Filová, Elena (FGU-C) RID
    Matějka, Roman (FGU-C) RID, ORCID, SAI
    Štěpanovská, Jana (FGU-C) ORCID, RID
    Musílková, Jana (FGU-C) RID, ORCID
    Zárubová, Jana (FGU-C) RID, ORCID
    Molitor, M. (CZ)
    Zdroj.dok.Muscle Cell and Tissue : Current Status of Research Field. - London : IntechOpen, 2018 / Sakuma Kunihiro - ISBN 978-1-78984-006-3
    Rozsah strans. 229-257
    Poč.str.29 s.
    Poč.str.knihy357
    Forma vydáníOnline - E
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovablood vessels ; smooth muscle cells ; contractile phenotype ; synthetic phenotype ; phenotypic modulation ; vascular diseases ; atherosclerosis ; hypertension ; developmental pathology
    Vědní obor RIVEI - Biotechnologie a bionika
    Obor OECDTechnologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
    CEPNV15-33018A GA MZd - Ministerstvo zdravotnictví
    ED1.1.00/02.0109 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaFGU-C - RVO:67985823
    DOI10.5772/intechopen.77115
    AnotaceVascular smooth muscle cells (VSMCs) play important roles not only in the physiological functions of the blood vessels, such as vasoconstriction, vasodilatation and extracellular matrix production, but also in the pathogenesis of vascular diseases, particularly atherosclerosis and hypertension. VSMCs are mostly of mesodermal origin, although some are of neuroectodermal origin, for example, VSMCs present in the aorta and in blood vessels arising from the aortic arch. VSMCs of neuroectodermal origin are implicated in defects of cardiovascular morphogenesis, such as bicuspid aortic valve, coarctation of the aorta, patent ductus arteriosus and tetralogy of Fallot. The origin, location in the vascular tree, gender, species, strain and age influence the phenotype of VSMCs and their propensity to migration and growth. In a healthy adult organism, VSMCs have a quiescent and differentiated contractile phenotype characterized by early markers (e.g., SM alpha-actin, SM22-alpha), intermediate markers (h-caldesmon, calponin) and late markers (SM myosins, smoothelin) of VSMC differentiation. However, after blood vessel injury, surgery or explantation in vitro, VSMCs undergo a phenotypic modulation to synthetic phenotype, which endows them with high activity in migration, growth and proteosynthesis. These features can lead to stenosis or to obliteration of the vascular lumen and impaired blood supply to various tissues and organs.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2019
Počet záznamů: 1