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Social defeat stimulates local glucocorticoid regeneration in lymphoid organs

SYSNO ASEP	0498848
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Social defeat stimulates local glucocorticoid regeneration in lymphoid organs
Tvůrce(i)	Ergang, Peter (FGU-C)_{RID, ORCID} Mikulecká, Anna (FGU-C)_{RID, ORCID} Vodička, Martin (FGU-C)_{RID, ORCID, SAI} Vagnerová, Karla (FGU-C)_{RID, ORCID} Mikšík, Ivan (FGU-C)_{RID, ORCID, SAI} Pácha, Jiří (FGU-C)_{RID, ORCID}
Zdroj.dok.	Endocrine Connections. - : BioScientifica - ISSN 2049-3614 Roč. 7, č. 12 (2018), s. 1389-1396
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	glucocorticoid metabolism ; lymhoid organs ; Lewis rats ; Fisher 344 rats ; social stress
Vědní obor RIV	ED - Fyziologie
Obor OECD	Physiology (including cytology)
CEP	GA15-07268S GA ČR - Grantová agentura ČR
	GA18-02993S GA ČR - Grantová agentura ČR
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000456847800027
EID SCOPUS	85065087914
DOI	10.1530/EC-18-0319
Anotace	Stress is an important risk factors for human diseases. It activates the hypothalamic-pituitary-adrenal (HPA) axis and increases plasma glucocorticoids, which are powerful regulators of immune system. The response of the target cells to glucocorticoids depends not only on the plasma concentrations of cortisol and corticosterone but also on their local metabolism. This metabolism is catalyzed by 1111-hydroxysteroid dehydrogenases type 1 and 2, which interconvert glucocorticoid hormones cortisol and corticosterone and their 11-oxo metabolites cortisone and 11-dehydrocorticosterone. The goal of this study was to determine whether stress modulates glucocorticoid metabolism within lymphoid organs - the structures where immune cells undergo development and activation. Using the resident-intruder paradigm, we studied the effect of social stress on glucocorticoid metabolism in primary and secondary lymphoid organs of Fisher 344 (F344) and Lewis (LEW) rats, which exhibit marked differences in their HPA axis response to social stressors and inflammation. We show that repeated social defeat increased the regeneration of corticosterone from 11-dehydrocorticosterone in the thymus, spleen and mesenteric lymphatic nodes (MLN). Compared with the F344 strain, LEW rats showed higher corticosterone regeneration in splenocytes of unstressed rats and in thymic and MLN mobile cells after stress but corticosterone regeneration in the stroma of all lymphoid organs was similar in both strains. Inactivation of corticosterone to 11-dehydrocorticosterone was found only in the stroma of lymphoid organs but not in mobile lymphoid cells and was not upregulated by stress. Together, our findings demonstrate the tissue- and strain-dependent regeneration of glucocorticoids following social stress.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2019

Počet záznamů: 1