Počet záznamů: 1
Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients
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SYSNO ASEP 0498773 Druh ASEP J - Článek v odborném periodiku Zařazení RIV Záznam nebyl označen do RIV Poddruh J Článek ve WOS Název Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients Tvůrce(i) Truxová, I. (CZ)
Kašíková, L. (CZ)
Hensler, M. (CZ)
Skapa, P. (CZ)
Laco, J. (CZ)
Pecen, Ladislav (UIVT-O) RID, SAI, ORCID
Belicová, L. (CZ)
Práznovec, I. (CZ)
Halaška, M. (CZ)
Brtnický, T. (CZ)
Šálková, E. (CZ)
Rob, L. (CZ)
Kodet, R. (CZ)
Goc, J. (FR)
Sautes-Fridman, C. (FR)
Fridman, W. H. (FR)
Ryška, A. (CZ)
Galluzzi, L. (US)
Špíšek, R. (CZ)
Fučíková, J. (CZ)Číslo článku 139 Zdroj.dok. Journal for ImmunoTherapy of Cancer
Roč. 6, 4 December (2018)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova CD8+ cytotoxic T lymphocytes ; DC-LAMP ; Dendritic cells ; Natural killer cells ; Tertiary lymphoid structures UT WOS 000452804900001 EID SCOPUS 85058319459 DOI 10.1186/s40425-018-0446-3 Anotace A high density of tumor-infiltrating CD8+ T cells and CD20+ B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP+ DCs is robustly associated with an immune contexture characterized by TH1 polarization and cytotoxic activity. We showed that both mature DCs and CD20+ B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP+ DCs and CD20+ B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP+ DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2019
Počet záznamů: 1