Počet záznamů: 1
Functional Evolution of Subolesin/Akirin
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SYSNO ASEP 0497446 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Functional Evolution of Subolesin/Akirin Tvůrce(i) Artigas-Jerónimo, S. (ES)
Villar, M. (ES)
Cabezas-Cruz, A. (FR)
Valdés, James J. (BC-A) RID, ORCID
Estrada-Pena, A. (ES)
Alberdi, P. (ES)
de la Fuente, J. (ES)Celkový počet autorů 7 Číslo článku 1612 Zdroj.dok. Frontiers in Physiology. - : Frontiers Research Foundation - ISSN 1664-042X
Roč. 9, NOV 13 (2018)Poč.str. 17 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova immune response ; vaccine ; interactome ; regulome ; phylogeny ; tick ; Anaplasma phagocytophilum Vědní obor RIV EC - Imunologie Obor OECD Biochemical research methods Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 000450038800004 EID SCOPUS 85057063669 DOI 10.3389/fphys.2018.01612 Anotace The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes. Here, we investigated the evolutionary history of Subolesin/Akirin with recent results on their structure, protein-protein interactions and function in different species to provide insights into the functional evolution of these regulatory proteins, and their potential as vaccine antigens for the control of ectoparasite infestations and pathogen infection. The results suggest that Subolesin/Akirin evolved conserving not only its sequence and structure, but also its function and role in cell interactome and regulome in response to pathogen infection and other biological processes. This functional conservation provides a platform for further characterization of the function of these regulatory proteins, and how their evolution can meet species-specific demands. Furthermore, the conserved functional evolution of Subolesin/Akirin correlates with the protective capacity shown by these proteins in vaccine formulations for the control of different arthropod and pathogen species. These results encourage further research to characterize the structure and function of these proteins, and to develop new vaccine formulations by combining Subolesin/Akirin with interacting proteins for the control of multiple ectoparasite infestations and pathogen infection. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2019 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fphys.2018.01612/full
Počet záznamů: 1