Počet záznamů: 1
Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water
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SYSNO ASEP 0494973 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water Tvůrce(i) Roberts, S.J. (GB)
Szabla, Rafal (BFU-R) ORCID
Todd, Z.R. (US)
Stairs, S. (GB)
Bucar, D.K. (GB)
Šponer, Jiří (BFU-R) RID, ORCID
Sasselov, D.D. (US)
Powner, M.W. (GB)Celkový počet autorů 8 Číslo článku 4073 Zdroj.dok. Nature Communications. - : Nature Publishing Group
Roč. 9, OCT 4 2018 (2018)Poč.str. 10 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova synthetic genetic polymers ; nucleic-acid structure ; polarization propagator ; hydrogen-peroxide ; chemical etiology ; excited-states ; rna world Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology Institucionální podpora BFU-R - RVO:68081707 UT WOS 000446313800008 DOI 10.1038/s41467-018-06374-z Anotace Prebiotic nucleotide synthesis is crucial to understanding the origins of life on Earth. There are numerous candidates for life's first nucleic acid, however, currently no prebiotic method to selectively and concurrently synthesise the canonical Watson-Crick base-pairing pyrimidine (C, U) and purine (A, G) nucleosides exists for any genetic polymer. Here, we demonstrate the divergent prebiotic synthesis of arabinonucleic acid (ANA) nucleosides. The complete set of canonical nucleosides is delivered from one reaction sequence, with regiospecific glycosidation and complete furanosyl selectivity. We observe photochemical 8-mercaptopurine reduction is efficient for the canonical purines (A, G), but not the noncanonical purine inosine (I). Our results demonstrate that synthesis of ANA may have been facile under conditions that comply with plausible geochemical environments on early Earth and, given that ANA is capable of encoding RNA/DNA compatible information and evolving to yield catalytic ANA-zymes, ANA may have played a critical role during the origins of life. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2019
Počet záznamů: 1