Počet záznamů: 1
Changing the threshold-Signals and mechanisms of mast cell priming
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SYSNO ASEP 0494578 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Changing the threshold-Signals and mechanisms of mast cell priming Tvůrce(i) Hálová, Ivana (UMG-J) RID, ORCID
Ronnberg, E. (SE)
Dráberová, Lubica (UMG-J) RID
Vliagoftis, H. (SE)
Nilsson, G.P. (SE)
Dráber, Petr (UMG-J) RIDCelkový počet autorů 6 Zdroj.dok. Immunological Reviews. - : Wiley - ISSN 0105-2896
Roč. 282, č. 1 (2018), s. 73-86Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova cell priming ; chemokines ; cytokine receptors ; cytokines ; high-affinity IgE receptor ; mast cell Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD 3.2 Clinical medicine CEP GA17-20255S GA ČR - Grantová agentura ČR GA17-20915S GA ČR - Grantová agentura ČR Institucionální podpora UMG-J - RVO:68378050 UT WOS 000424876400006 DOI 10.1111/imr.12625 Anotace Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (Fc epsilon RIs). Aggregation of Fc epsilon RIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes. Mast cell priming changes the threshold for antigen-mediated activation by various mechanisms, depending on the priming agent used, which alone usually do not induce mast cell degranulation. In this review, we describe the priming processes induced in mast cells by various cytokines (stem cell factor, interleukins-4,6 and33), chemokines, other agents acting through G protein-coupled receptors (adenosine, prostaglandin E-2, sphingosine-1-phosphate, and beta-2-adrenergic receptor agonists), toll-like receptors, and various drugs affecting the cytoskeleton. We will review the current knowledge about the molecular mechanisms behind priming of mast cells leading to degranulation and cytokine production and discuss the biological effects of mast cell priming induced by several cytokines. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2019
Počet záznamů: 1