Počet záznamů: 1
N-(2-hydroxypropyl)methacrylamide-based linear, diblock, and starlike polymer drug carriers: advanced process for their simple production
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SYSNO ASEP 0494320 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název N-(2-hydroxypropyl)methacrylamide-based linear, diblock, and starlike polymer drug carriers: advanced process for their simple production Tvůrce(i) Koziolová, Eva (UMCH-V) RID, ORCID
Kostka, Libor (UMCH-V) RID, ORCID
Kotrchová, Lenka (UMCH-V) RID, ORCID
Šubr, Vladimír (UMCH-V) RID, ORCID
Konefal, Rafal (UMCH-V) RID, ORCID
Nottelet, B. (FR)
Etrych, Tomáš (UMCH-V) RID, ORCIDZdroj.dok. Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 19, č. 10 (2018), s. 4003-4013Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova HPMA ; star-like carriers ; deprotection Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA17-13283S GA ČR - Grantová agentura ČR NV16-28600A GA MZd - Ministerstvo zdravotnictví LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000447118500010 EID SCOPUS 85053918557 DOI 10.1021/acs.biomac.8b00973 Anotace We developed a new simplified method for the synthesis of well-defined linear, diblock, or starlike N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer drug carriers using controlled reversible addition-fragmentation chain transfer polymerization. The prepared monodispersed polymers are after the drug attachment intended for enhanced anticancer therapy. This new approach significantly reduces the number of required synthetic steps and minimizes the consumption of organic solvents during the synthesis. As a result, highly defined linear, diblock, and starlike copolymers designed for pH-triggered drug activation/release in tumor tissue were formed in sufficient amounts for further physicochemical and biological studies. Within the synthesis, we also developed a new procedure for the selective deprotection of tert-butoxycarbonyl hydrazide and amine groups on hydrophilic HPMA copolymers, including the one-pot removal of polymer end groups. We studied and described in detail the kinetics and efficacy of the deprotection reaction. We believe the simplified synthetic approach facilitates the preparation of polymer conjugates bound by the pH-sensitive hydrazone bond and their application in tumor treatment. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2019
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