Počet záznamů: 1
Polyphasic data support the splitting of Aspergillus candidus into two species, proposal of Aspergillus dobrogensis sp nov.
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SYSNO ASEP 0494189 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polyphasic data support the splitting of Aspergillus candidus into two species, proposal of Aspergillus dobrogensis sp nov. Tvůrce(i) Hubka, Vít (MBU-M) ORCID
Nováková, Alena (MBU-M) ORCID
Jurjević, Ž. (US)
Sklenář, František (MBU-M) ORCID
Frisvad, J.C. (DK)
Houbraken, J. (NL)
Arendrup, M.C. (DK)
Jorgensen, K.M. (DK)
Sigueira, J.P.Z. (ES)
Gené, J. (ES)
Kolařík, Miroslav (MBU-M) RID, ORCIDZdroj.dok. International Journal of Systematic and Evolutionary Microbiology. - : Microbiology Society - ISSN 1466-5026
Roč. 68, č. 4 (2018), s. 995-1011Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova antifungal susceptibility testing ; antioxidant compounds ; bioprospecting Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP GA17-20286S GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora MBU-M - RVO:61388971 UT WOS 000433170100004 EID SCOPUS 85044924162 DOI 10.1099/ijsem.0.002583 Anotace Aspergillus candidus is a species frequently isolated from stored grain, food, indoor environments, soil and occasionally also from clinical material. Recent bioprospecting studies highlighted the potential of using A. candidus and its relatives in various industrial sectors as a result of their significant production of enzymes and bioactive compounds. A high genetic variability was observed among A. candidus isolates originating from various European countries and the USA, that were mostly isolated from indoor environments, caves and clinical material. The A. candidus sensu lato isolates were characterized by DNA sequencing of four genetic loci, and agreement between molecular species delimitation results, morphological characters and exometabolite spectra were studied. Classical phylogenetic methods (maximum likelihood, Bayesian inference) and species delimitation methods based on the multispecies coalescent model supported recognition of up to three species in A. candidus sensu lato. After evaluation of phenotypic data, a broader species concept was adopted, and only one new species, Aspergillus dobrogensis, was proposed. This species is represented by 22 strains originating from seven countries (ex-type strain CCF 4651(T) = NRRL 62821(T) = IBT 32697(T) = CBS 143370(T)) and its differentiation from A. candidus is relevant for bioprospecting studies because these species have different exometabolite profiles. Evaluation of the antifungal susceptibility of section Candidi members to six antifungals using the reference EUCAST method showed that all species have low minimum inhibitory concentrations for all tested antifungals. These results suggest applicability of a wide spectrum of antifungal agents for treatment of infections caused by species from section Candidi. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2019
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