Počet záznamů: 1
Printing inks of electroactive polymer PEDOT:PSS: The study of biocompatibility, stability, and electrical properties
- 1.
SYSNO ASEP 0492424 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Printing inks of electroactive polymer PEDOT:PSS: The study of biocompatibility, stability, and electrical properties Tvůrce(i) Stříteský, S. (CZ)
Marková, A. (CZ)
Víteček, Jan (BFU-R) RID, ORCID
Šafaříková, Eva (BFU-R)
Hrabal, M. (CZ)
Kubáč, L. (CZ)
Kubala, Lukáš (BFU-R) RID, ORCID
Weiter, M. (CZ)
Vala, M. (CZ)Celkový počet autorů 9 Zdroj.dok. Journal of Biomedical Materials Research. Part A. - : Wiley - ISSN 1549-3296
Roč. 106, č. 4 (2018), s. 1121-1128Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova organic electrochemical transistors ; cells ; culture ; bisensors Vědní obor RIV BO - Biofyzika Obor OECD Biophysics CEP GA13-29358S GA ČR - Grantová agentura ČR GA17-24707S GA ČR - Grantová agentura ČR Institucionální podpora BFU-R - RVO:68081707 UT WOS 000426512100025 DOI 10.1002/jbm.a.36314 Anotace Biocompatibility tests and a study of the electrical properties of thin films prepared from six electroactive polymer ink formulations based on poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) were performed. The aim was to find a suitable formulation of PEDOT:PSS and conditions for preparing thin films in order to construct printed bioelectronic devices for biomedical applications. The stability and electrical properties of such films were tested on organic electrochemical transistor (OECT)-based sensor platforms and their biocompatibility was evaluated in assays with 3T3 fibroblasts and murine cardiomyocytes. It was found that the thin films prepared from inks without an additive or any thin film post-treatment provide limited conductivity and stability for use in biomedical applications. These properties were greatly improved by using ethylene glycol and thermal annealing. Addition or post-treatment by ethylene glycol in combination with thermal annealing provided thin films with electrical resistance and a stability sufficient to be used in sensing of animal cell physiology. These films coated with collagen IV showed good biocompatibility in the assay with 3T3 fibroblasts when compared to standard cell culture plastics. Selected films were then used in assays with murine cardiomyocytes. We observed that these cells were able to attach to the PEDOT:PSS films and form an active sensor element. Spontaneously beating clusters were formed, indicating a good physiological status for the cardiomyocyte cells. These results open the door to construction of cheap printed electronic devices for biointerfacing in biomedical applications. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1121-1128, 2018. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2019
Počet záznamů: 1