Počet záznamů: 1
Biocatalytic production of mandelic acid and analogues: a review and comparison with chemical processes
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SYSNO ASEP 0489455 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biocatalytic production of mandelic acid and analogues: a review and comparison with chemical processes Tvůrce(i) Martínková, Ludmila (MBU-M) RID, ORCID
Křen, Vladimír (MBU-M) RID, ORCIDZdroj.dok. Applied Microbiology and Biotechnology. - : Springer - ISSN 0175-7598
Roč. 102, č. 9 (2018), s. 3893-3900Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Mandelic acid ; Nitrilase ; Lipase Vědní obor RIV EI - Biotechnologie a bionika Obor OECD Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation CEP GA18-00184S GA ČR - Grantová agentura ČR LTC17009 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora MBU-M - RVO:61388971 UT WOS 000429800600005 EID SCOPUS 85043400740 DOI 10.1007/s00253-018-8894-8 Anotace The aim of this study is to summarize the current progress in the design of biocatalytic processes applicable for the production of optically pure mandelic acids and their analogues. These compounds are used as building blocks for pharmaceutical chemistry and as chiral resolving agents. Their enzymatic syntheses mainly employed nitrile hydrolysis with nitrilases, ester hydrolysis, ammonolysis or esterification with lipases or esterases, and ketone reduction or alcohol oxidation with dehydrogenases. Each of these methods will be characterized in terms of its product concentrations, enantioselectivities, and the types of catalysts used. This review will focus on the dynamic kinetic resolution of mandelonitrile and analogues by nitrilases resulting in the production of high concentrations of (R)-mandelic acid or (R)-2-chloromandelic acid with excellent e.e. Currently, there is no comparable process for (S)-mandelic acids. However, the coupling of the S-selective cyanation of benzaldehyde with the enantioretentive hydrolysis of (S)-mandelonitrile thus obtained is a promising strategy. The major product can be changed from (S)-acid to (S)-amide using nitrilase mutants. The competitiveness of the biocatalytic and chemical processes will be assessed. This review covers the literature published within 2003-2017. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2019
Počet záznamů: 1