Počet záznamů: 1
Probes & Drugs portal: an interactive, open data resource for chemical biology
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SYSNO ASEP 0487037 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Probes & Drugs portal: an interactive, open data resource for chemical biology Tvůrce(i) Škuta, Ctibor (UMG-J)
Popr, M. (CZ)
Muller, Tomáš (UMG-J)
Jindřich, Jindřich (UMG-J)
Kahle, Michal (UMG-J)
Sedlák, David (UMG-J) RID
Svozil, Daniel (UMG-J)
Bartůněk, Petr (UMG-J) RIDCelkový počet autorů 8 Zdroj.dok. Nature Methods. - : Nature Publishing Group - ISSN 1548-7091
Roč. 14, č. 8 (2017), s. 758-759Poč.str. 2 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova bioactive compound, ,, ; chemical probe ; chemical biology ; portal Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) CEP LO1220 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMG-J - RVO:68378050 UT WOS 000406493800005 DOI 10.1038/nmeth.4365 Anotace We report the Probes & Drugs (P&D) portal (https://www.probes-drugs.org), a powerful tool for the exploration of bioactive compound space. Chemical probes are indispensable tools in modern biology. These compounds are commonly used to study gene function, validate molecular targets or dissect complex processes within cells and organisms1,2,3. Unlike drugs, which are effective, bioavailable and safe compounds, a probe's main attributes reside in its potency, selectivity and well-defined mechanism of action. Yet identifying chemical probes that meet all the demands of an experimental design is not a trivial task. Information on candidate probes and their potency, mechanism of action or availability is typically scattered over various sources, and gathering such information can be very time consuming. In some cases, probe annotations may even be out of date, and this propagates the continued selection of probes in which the biological characteristics have been disproven and their suitability questioned4,5. Many of these compounds remain incorporated in commercial screening libraries and continue to be used by the community5,6. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2018
Počet záznamů: 1