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/GD-Tracker/ A software for blood-brain barrier permeability assessment
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SYSNO ASEP 0482636 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve SCOPUS Název /GD-Tracker/ A software for blood-brain barrier permeability assessment Tvůrce(i) Kala, David (FGU-C)
Svoboda, Jan (FGU-C)
Litvinec, Andrej (FGU-C)
Pošusta, Antonín (FGU-C) RID
Lisý, J. (CZ)
Šulc, V. (CZ)
Tomek, A. (CZ)
Marusič, P. (CZ)
Jiruška, Přemysl (FGU-C) RID, ORCID, SAI
Otáhal, Jakub (FGU-C) RID, ORCID, SAIZdroj.dok. Lékař a technika. Biomedicinské inženýrství a informatika. - : Česká lékařská společnost J. E. Purkyně - ISSN 0301-5491
Roč. 47, č. 2 (2017), s. 43-48Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova blood-brain barrier ; MRI ; Gd-DTPA ; permeability ; stroke ; epileptogenesis ; MATLAB ; freeware ; Gd-Tracker Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP NV15-33115A GA MZd - Ministerstvo zdravotnictví LM2015062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 EID SCOPUS 85027324258 Anotace Epilepsy is chronic neurological disease characterized by occurrence of spontaneous recurrent seizures affecting approximately 1% of people. One of the most common causes of epilepsy in adults is a stroke. The precise mechanism of development of vascular epilepsy is not known, and thus no reliable biomarker of postischemic epileptogenesis currently exists. Blood-brain barrier (BBB) impairment is phenomenon observed in several pathologies including stroke after which epilepsy often develops. Blood components such as albumin or thrombin have been experimentally shown to possess the capacity to increase excitability which results in seizures and epileptogenesis. We hypothesize that severity of the BBB breakdown during first weeks after the stroke can be used as a biomarker of postischemic epileptogenesis. This paper describes free MATLAB based software /Gd-Tracker/ and methodology developed for assessment of BBB permeability from magnetic resonance (MR) scans based on statistical voxel to voxel comparison of sequences with and without Gd-DTPA contrast. This software allows to evaluate extent and magnitude of impaired BBB region and thus serve as a tool for visualization and quantification of BBB breakdown. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2018
Počet záznamů: 1