Počet záznamů: 1
The role of nitric oxide during embryonic epidermis development of Xenopus laevis
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SYSNO ASEP 0482593 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of nitric oxide during embryonic epidermis development of Xenopus laevis Tvůrce(i) Tománková, Silvie (BTO-N) RID
Abaffy, Pavel (BTO-N)
Šindelka, Radek (BTO-N) RIDCelkový počet autorů 3 Zdroj.dok. Biology Open. - : Company of Biologists - ISSN 2046-6390
Roč. 6, č. 6 (2017), s. 862-871Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Development ; Nitric oxide ; Epidermis ; Xenopus laevis Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Developmental biology CEP LK21305 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LH15074 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora BTO-N - RVO:86652036 UT WOS 000403449400015 DOI 10.1242/bio.023739 Anotace Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and its downstream targets. Here we report the essential role of NO during embryonic epidermis development. Xenopus embryonic epidermis has become a useful model reflecting human epithelial tissue composition. The developing epidermis of Xenopus laevis is formed from specialized ionocytes, multi-ciliated, goblet and small secretory cells. We found that NO is mainly produced in multi-ciliated cells and ionocytes. Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal-specific gene expression. The data from this research indicate a novel role of NO during development, which supports recent findings of NO production in human mucociliary and epithelium development. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2018
Počet záznamů: 1