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Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology
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SYSNO ASEP 0479525 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology Tvůrce(i) Pantalacci, S. (FR)
Gueguen, L. (FR)
Petit, C. (FR)
Lambert, A. (FR)
Peterková, Renata (UEM-P) RID
Sémon, E. (FR)Zdroj.dok. Genome Biology - ISSN 1474-760X
Roč. 18, feb (2017), s. 29Poč.str. 25 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova comparative transcriptomics ; developmental biology ; transcriptomic signature Vědní obor RIV EA - Morfologické obory a cytologie Obor OECD Developmental biology CEP GB14-37368G GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 UT WOS 000394827900001 EID SCOPUS 85013211607 DOI 10.1186/s13059-017-1157-7 Anotace Little is known about the kinds of expression differences that shape the patterns during development. Using mouse model of odontogenesis, the transcriptomes were compared and correlated with the development of two morphologically distinct serial organs: the upper and lower first molars that exhibit specific tooth morphology and cusp pattern. 1) The, lower/upper molar differences were maintained throughout morphogenesis and stem from differences in the relative abundance of mesenchyme and from constant differences in gene expression within tissues. 2) There were clear time-shift differences in the transcriptomes of the two molars related to cusp tissue abundance. 3) The transcriptomes corresponded to exaggerated morphogenetic processes in the upper molar involving fewer mitotic cells but more migrating cells.
CONCLUSIONS: Gene expression in a complex tissue reflects not only transcriptional regulation but also abundance of different cell types.
Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2018
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