Počet záznamů: 1  

Diffusion of Integral Membrane Proteins in Protein-Rich Membranes

  1. 1.
    SYSNO ASEP0479162
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevDiffusion of Integral Membrane Proteins in Protein-Rich Membranes
    Tvůrce(i) Javanainen, M. (FI)
    Martinez-Seara, Hector (UOCHB-X) RID, ORCID
    Metzler, R. (DE)
    Vattulainen, I. (FI)
    Zdroj.dok.Journal of Physical Chemistry Letters - ISSN 1948-7185
    Roč. 8, č. 17 (2017), s. 4308-4313
    Poč.str.6 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovagiant unilamellar vesicles ; single-molecule tracking ; lipid bilayer membranes
    Vědní obor RIVCF - Fyzikální chemie a teoretická chemie
    Obor OECDPhysical chemistry
    CEPGBP208/12/G016 GA ČR - Grantová agentura ČR
    Institucionální podporaUOCHB-X - RVO:61388963
    UT WOS000410600600057
    EID SCOPUS85029075508
    DOI10.1021/acs.jpclett.7b01758
    AnotaceThe lateral diffusion of embedded proteins along lipid membranes in protein-poor conditions has been successfully described in terms of the Saffman-Delbruck (SD) model, which predicts that the protein diffusion coefficient D is weakly dependent on its radius R as D proportional to ln(1/R). However, instead of being protein-poor, native cell membranes are extremely crowded with proteins. On the basis of extensive molecular simulations, we here demonstrate that protein crowding of the membrane at physiological levels leads to deviations from the SD relation and to the emergence of a stronger Stokes-like dependence D proportional to 1/R. We propose that this 1/R law mainly arises due to geometrical factors: smaller proteins are able to avoid confinement effects much better than their larger counterparts. The results highlight that the lateral dynamics in the crowded setting found in native membranes is radically different from protein-poor conditions and plays a significant role in formation of functional multiprotein complexes.
    PracovištěÚstav organické chemie a biochemie
    KontaktJana Procházková, janap@uochb.cas.cz, Tel.: 220 183 418 ; Viktorie Chládková, viktorie.chladkova@uochb.cas.cz, Tel.: 232 002 434
    Rok sběru2018