Počet záznamů: 1
A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties
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SYSNO ASEP 0478919 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties Tvůrce(i) Bukin, Y. S. (RU)
Dzhioev, Y. (RU)
Tkachev, S. E. (RU)
Kozlova, I. (RU)
Paramonov, A. I. (RU)
Růžek, Daniel (BC-A) RID, ORCID
Qu, Z. (CN)
Zlobin, V. I. (RU)Celkový počet autorů 8 Zdroj.dok. Virus Research. - : Elsevier - ISSN 0168-1702
Roč. 238, JUN 15 (2017), s. 124-132Poč.str. 9 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova tick-borne encephalitis virus ; E protein ; physicochemical properties amino acid residue ; antigen ; antibody Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Virology Institucionální podpora BC-A - RVO:60077344 UT WOS 000408077500017 EID SCOPUS 85021694350 DOI 10.1016/j.virusres.2017.06.006 Anotace This work is dedicated to the study of the variability of the main antigenic envelope protein E among different strains of tick-borne encephalitis virus at the level of physical and chemical properties of the amino acid residues. E protein variants were extracted from then NCBI database. Four amino acid residues properties in the polypeptide sequences were investigated: the average volume of the amino acid residue in the protein tertiary structure, the number of amino acid residue hydrogen bond donors, the charge of amino acid residue lateral radical and the dipole moment of the amino acid residue. These physico-chemical properties are involved in antigen-antibody interactions. As a result, 103 different variants of the antigenic determinants of the tick-borne encephalitis virus E protein were found, significantly different by physical and chemical properties of the amino acid residues in their structure. This means that some strains among the natural variants of tick-borne encephalitis virus can potentially escape the immune response induced by the standard vaccine. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2018
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