Počet záznamů: 1

Transcriptomic response of Arabidopsis thaliana (L.) Heynh. roots to ibuprofen

SYSNO ASEP	0476651
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Transcriptomic response of Arabidopsis thaliana (L.) Heynh. roots to ibuprofen
Tvůrce(i)	Landa, Přemysl (UEB-Q)_{RID, ORCID} Přerostová, Sylva (UEB-Q)_{RID, ORCID, SAI} Langhansová, Lenka (UEB-Q)_{RID, ORCID} Maršík, Petr (UEB-Q)_{RID, ORCID} Vaněk, Tomáš (UEB-Q)_{RID, ORCID}
Celkový počet autorů	5
Zdroj.dok.	International Journal of Phytoremediation. - : Taylor & Francis - ISSN 1522-6514 Roč. 19, č. 8 (2017), s. 695-700
Poč.str.	6 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	detoxification ; gene expression ; metabolism of xenobiotics ; microarrays ; phytoremediation
Vědní obor RIV	CE - Biochemie
Obor OECD	Plant sciences, botany
CEP	GA14-22593S GA ČR - Grantová agentura ČR
Institucionální podpora	UEB-Q - RVO:61389030
UT WOS	000402041800001
EID SCOPUS	85019615193
DOI	10.1080/15226514.2016.1267697
Anotace	Surface waters in urban areas are contaminated by ibuprofen (IBP), a popular and extensively used anti-inflammatory drug. In this study, we investigated the transcriptomic response in Arabidopsis thaliana (L.) Heynh. roots with the aim of revealing genes that are potentially involved in IBP detoxification and elucidating the effect of IBP on plants. IBP upregulated 63 and downregulated 38 transcripts (p-value < 0.1, fold change ≥2) after 2-day exposure to a 5-µM (1.03 mg/L) concentration of IBP under hydroponic conditions. Although the IBP concentration used in the experiment was highly relative to the concentrations found in rivers and wastewater, the number of genes with transcriptional changes was relatively low. The upregulation of cytochrome P450s, glutathione S-transferases, and UDP-glycosyltransferases indicates the occurrence of IBP oxidation in the first phase, followed by conjugation with glutathione and sugar in the second detoxification phase. ABC transporters could be involved in the transport of IBP and its metabolites. The identification of genes potentially involved in IBP detoxification could be useful in an IBP phytoremediation approach.
Pracoviště	Ústav experimentální botaniky
Kontakt	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Rok sběru	2018

Počet záznamů: 1