Počet záznamů: 1

Glycosylation of voltage-gated calcium channels in health and disease

SYSNO ASEP	0475298
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Glycosylation of voltage-gated calcium channels in health and disease
Tvůrce(i)	Lazniewska, Joanna (UOCHB-X)_ORCID Weiss, Norbert (UOCHB-X)_{ORCID, RID}
Zdroj.dok.	Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736 Roč. 1859, č. 5 (2017), s. 662-668
Poč.str.	7 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	calcium channels ; voltage-gated calcium channels ; N-glycosylation ; ancillary subunit ; trafficking ; stability
Vědní obor RIV	CE - Biochemie
Obor OECD	Biochemistry and molecular biology
CEP	GA15-13556S GA ČR - Grantová agentura ČR
	7AMB15FR015 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UOCHB-X - RVO:61388963
UT WOS	000398870800002
EID SCOPUS	85012113504
DOI	10.1016/j.bbamem.2017.01.018
Anotace	Voltage-gated calcium channels (VGCCs) are transmembrane proteins that translate electrical activities into intracellular calcium elevations and downstream signaling pathways. They serve essential physiological functions including communication between nerve cells, muscle contraction, cardiac activity, and release of hormones and neurotransmitters. Asparagine-linked glycosylation has emerged as an essential post-translational modification to control the number of channels embedded in the plasma membrane but also their functional gating properties. This review provides a comprehensive overview about the current state of knowledge on the role of glycosylation in the expression and functioning of VGCCs, and discusses how variations in the glycosylation of the channel proteins can contribute to pathological conditions.
Pracoviště	Ústav organické chemie a biochemie
Kontakt	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Rok sběru	2018

Počet záznamů: 1