Počet záznamů: 1
Polymer brush-functionalized chitosan hydrogels as antifouling implant coatings
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SYSNO ASEP 0475191 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polymer brush-functionalized chitosan hydrogels as antifouling implant coatings Tvůrce(i) Buzzacchera, I. (NL)
Vorobii, M. (DE)
Kostina, N. Yu. (DE)
de los Santos Pereira, Andres (UMCH-V) RID, ORCID
Riedel, Tomáš (UMCH-V) RID, ORCID
Bruns, M. (DE)
Ogieglo, W. (DE)
Möller, M. (DE)
Wilson, C. J. (NL)
Rodriguez-Emmenegger, C. (DE)Zdroj.dok. Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 18, č. 6 (2017), s. 1983-1992Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova chitosan ; hemocompatible ; polymer brushes Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GBP205/12/G118 GA ČR - Grantová agentura ČR Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000403387100031 EID SCOPUS 85020692084 DOI 10.1021/acs.biomac.7b00516 Anotace Implantable sensor devices require coatings that efficiently interface with the tissue environment to mediate biochemical analysis. In this regard, bioinspired polymer hydrogels offer an attractive and abundant source of coating materials. However, upon implantation these materials generally elicit inflammation and the foreign body reaction as a consequence of protein fouling on their surface and concomitant poor hemocompatibility. In this report we investigate a strategy to endow chitosan hydrogel coatings with antifouling properties by the grafting of polymer brushes in a “grafting-from” approach. Chitosan coatings were functionalized with polymer brushes of oligo(ethylene glycol) methyl ether methacrylate and 2-hydroxyethyl methacrylate using photoinduced single electron transfer living radical polymerization and the surfaces were thoroughly characterized by XPS, AFM, water contact angle goniometry, and in situ ellipsometry. The antifouling properties of these new bioinspired hydrogel-brush coatings were investigated by surface plasmon resonance. The influence of the modifications to the chitosan on hemocompatibility was assessed by contacting the surfaces with platelets and leukocytes. The coatings were hydrophilic and reached a thickness of up to 180 nm within 30 min of polymerization. The functionalization of the surface with polymer brushes significantly reduced the protein fouling and eliminated platelet activation and leukocyte adhesion. This methodology offers a facile route to functionalizing implantable sensor systems with antifouling coatings that improve hemocompatibility and pave the way for enhanced device integration in tissue. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2018
Počet záznamů: 1