Počet záznamů: 1
Mechanisms of hormonal regulation of the peripheral circadian clock in the colon
- 1.
SYSNO ASEP 0473974 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mechanisms of hormonal regulation of the peripheral circadian clock in the colon Tvůrce(i) Polidarová, Lenka (FGU-C) RID, ORCID
Houdek, Pavel (FGU-C) ORCID
Sládek, Martin (FGU-C) RID, ORCID, SAI
Novosadová, Zuzana (FGU-C) ORCID
Pácha, Jiří (FGU-C) RID, ORCID
Sumová, Alena (FGU-C) RID, ORCIDZdroj.dok. Chronobiology International - ISSN 0742-0528
Roč. 34, č. 1 (2017), s. 1-16Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova circadian clock ; colon ; entrainment Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GA14-07711S GA ČR - Grantová agentura ČR GA13-08304S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000396728000001 EID SCOPUS 84988640233 DOI 10.1080/07420528.2016.1231198 Anotace Colonic function is controlled by an endogenous clock that allows the colon to optimize its function on the daytime basis. For the first time, this study provided evidence that the clock is synchronized by rhythmic hormonal signals. In rat colon, adrenalectomy decreased and repeated applications of dexamethasone selectively rescued circadian rhythm in the expression of the clock gene Per1. Dexamethasone entrained the colonic clock in explants from mPer2Luc mice in vitro. In contrast, pinealectomy had no effect on the rat colonic clock, and repeated melatonin injections were not able to rescue the clock in animals maintained in constant light. Additionally, melatonin did not entrain the clock in colonic explants from mPer2Luc mice in vitro. However, melatonin affected rhythmic regulation of Nr1d1 gene expression in vivo. The findings provide novel insight into possible beneficial effects of glucocorticoids in the treatment of digestive tract-related diseases, greatly exceeding their anti-inflammatory action. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2018
Počet záznamů: 1