Pharmacological caspase inhibitors: Research towards therapeutic perspectives
1.
SYSNO ASEP
0473501
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Článek ve WOS
Název
Pharmacological caspase inhibitors: Research towards therapeutic perspectives
Tvůrce(i)
Kudělová, J. (CZ) Fleischmannová, J. (CZ) Adamová, E. (CZ) Matalová, Eva (UIACH-O)
Zdroj.dok.
Journal of Physiology and Pharmacology. - : Polskie Towarzystwo Fizjologiczne
- ISSN 0867-5910
Roč. 66, č. 4 (2015), s. 473-482
Poč.str.
10 s.
Forma vydání
Tištěná - P
Jazyk dok.
eng - angličtina
Země vyd.
PL - Polsko
Klíč. slova
caspase ; caspase inhibitor ; apoptosis
Vědní obor RIV
CB - Analytická chemie, separace
CEP
GA14-28254S GA ČR - Grantová agentura ČR
Institucionální podpora
UIACH-O - RVO:68081715
UT WOS
000361499800001
EID SCOPUS
84940744287
Anotace
Caspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications.
