Počet záznamů: 1
Impact of Air Pollution to Genome of Newborns.
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SYSNO ASEP 0472879 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Impact of Air Pollution to Genome of Newborns. Tvůrce(i) Šrám, Radim (UEM-P) RID
Rössner ml., Pavel (UEM-P) RID, ORCID
Rössnerová, Andrea (UEM-P) RID
Dostál, Miroslav (UEM-P) RID
Milcová, Alena (UEM-P)
Švecová, Vlasta (UEM-P) RID
Pulkrabová, J. (CZ)
Hajšlová, J. (CZ)
Velemínský Jr., M. (CZ)Zdroj.dok. Central European Journal of Public Health. - : Státní zdravotní ústav - ISSN 1210-7778
Roč. 24, dec (2016), S40-S44Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova air pollution ; diet ; genetic damage ; molecular epidemiology Vědní obor RIV DN - Vliv životního prostředí na zdraví CEP GA13-13458S GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 UT WOS 000394081000006 EID SCOPUS 85011977163 DOI 10.21101/cejph.a4536 Anotace The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM2.5) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2017
Počet záznamů: 1