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The Biology and Therapeutic Applications of Mesenchymal Cells
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SYSNO ASEP 0472194 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název The role of mesenchymal stromal cells in spinal cord injury Tvůrce(i) Jendelová, Pavla (UEM-P) RID, ORCID
Machová-Urdzíková, Lucia (UEM-P) ORCID
Syková, Eva (UEM-P) RIDZdroj.dok. The Biology and Therapeutic Applications of Mesenchymal Cells. - Oxford : Wiley-Blackwell, 2017 / Atkinson Kerry - ISBN 978-1-118-90751-1 Rozsah stran s. 714-729 Poč.str. 16 s. Poč.str.knihy 1048 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova mesenchymal stromal cells ; bone marrow ; adipose tissue ; umbilical cord ; spinal cord injury ; clinical trials ; therapeutic use ; paracrine effect Vědní obor RIV FP - Ostatní lékařské obory Obor OECD Neurosciences (including psychophysiology CEP LO1309 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UEM-P - RVO:68378041 Anotace Spinal cord injury (SCI) is one of the most devastating diseases that affects patients and their families for the rest of their lives. Among many treatments being developed for SCI, the placement of different types of grafts embedded with cell populations into areas of damage has been one of the most commonly used
regenerative approaches ,attracting scientists and physicians for the last 15 years. Stem/stromal cells are able to secrete a large repertoire of signaling molecules, including anti-inflammatory cytokines and growth factors, which may modulate the inhibitory environment of SCI while increasing trophic support to the resident cells. The chapter describes the pathology of spinal cord injury, the use of mesenchymal stromal cells derived from different sources in the treatment of SCI and their potential modifications and manipulations to reinforce their paracrine effect on neural tissue regeneration.
Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2018
Počet záznamů: 1