Počet záznamů: 1
One OdontogenicCell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule
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SYSNO ASEP 0470568 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název One OdontogenicCell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule Tvůrce(i) Hovořáková, Mária (UEM-P) RID
Lochovská, Kateřina (UEM-P)
Zahradníček, Oldřich (UEM-P) RID
Domonkosová Tibenská, K. (SK)
Dornhoferová, M. (SK)
Horáková Smrčková, Lucie (UEM-P)
Bodoriková, S. (SK)Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 11, č. 9 (2016), e0162523Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova deciduous dentition ; tooth development ; human embryos Vědní obor RIV EB - Genetika a molekulární biologie CEP GAP305/12/1766 GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 UT WOS 000383255900122 EID SCOPUS 84990978740 DOI 10.1371/journal.pone.0162523 Anotace The area of the oral vestibule is often a place where pathologies appear (e.g., peripheral odontomas). The origin of these pathologies is not fully understood. In the present study, we traced a cell population expressing Sonic hedgehog (Shh) from the beginning of tooth development using Cre-LoxP system in the lower jaw of wild-type (WT) mice. We focused on Shh expression in the area of the early appearing rudimentaryincisor germs located anteriorly to the prospective incisors. The localization of the labelled cells in the incisor germs and also in the inner epithelial layer of the vestibular anlage showed that the first very early developmental events in the lower incisor area are common to the vestibulum oris and the prospective incisor primordia in mice. Scanning electron microscopic analysis of human historical tooth-like structures found in the vestibular area of jaws confirmedtheir relation to teeth and thus the capability of the vestibular tissue to form teeth. The location of labelled cells descendant of the early appearing Shh expression domain related to the rudimentary incisor anlage not only in the rudimentary and functional incisor germs but also in the externally located anlage of the oral vestibule documented the odontogenic potential of the vestibular epithelium. This potential can be awakened under pathological conditions and become a source of pathologies in the vestibular area. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2017
Počet záznamů: 1