Počet záznamů: 1
Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids
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SYSNO ASEP 0468794 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Post-transcriptional mending of gene sequences: looking under the hood of mitochondrial gene expression in diplonemids Tvůrce(i) Valach, M. (CA)
Moreira, S. (CA)
Faktorová, Drahomíra (BC-A) RID, ORCID
Lukeš, Julius (BC-A) RID, ORCID
Burger, G. (CA)Zdroj.dok. RNA biology. - : Taylor & Francis - ISSN 1547-6286
Roč. 13, č. 12 (2016), s. 1204-1211Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Cryptic genes ; gene fragmentation ; trans-splicing ; RNA editing ; multipartite mtDNA ; diplonemids Vědní obor RIV EB - Genetika a molekulární biologie CEP GA15-21974S GA ČR - Grantová agentura ČR Institucionální podpora BC-A - RVO:60077344 UT WOS 000390670300005 EID SCOPUS 85003794187 DOI 10.1080/15476286.2016.1240143 Anotace The instructions to make proteins and structural RNAs are laid down in gene sequences. Yet, in certain instances, these primary instructions need to be modified considerably during gene expression, most often at the transcript level. Here we review a case of massive post-transcriptional revisions via trans-splicing and RNA editing, a phenomenon occurring in mitochondria of a recently recognized protist group, the diplonemids. As of now, the various post-transcriptional steps have been cataloged in detail, but how these processes function is still unknown. Since genetic manipulation techniques such as gene replacement and RNA interference have not yet been established for these organisms, alternative strategies have to be deployed. Here, we discuss the experimental and bioinformatics approaches that promise to unravel the molecular machineries of trans-splicing and RNA editing in Diplonema mitochondria. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2017
Počet záznamů: 1