Počet záznamů: 1  

Image-Based Modeling of Blood Flow and Oxygen Transfer in Feto-Placental Capillaries

  1. 1.
    SYSNO ASEP0467394
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevImage-Based Modeling of Blood Flow and Oxygen Transfer in Feto-Placental Capillaries
    Tvůrce(i) Pearce, P. (GB)
    Brownbill, P. (GB)
    Janáček, Jiří (FGU-C) RID
    Jirkovská, M. (CZ)
    Kubínová, Lucie (FGU-C) RID
    Chernyavsky, I. L. (GB)
    Jensen, O. E. (GB)
    Číslo článkue0165369
    Zdroj.dok.PLoS ONE
    Roč. 11, č. 10 (2016)
    Poč.str.22 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaplacenta ; capillaries ; oxygen transfer ; confocal microscopy
    Vědní obor RIVEA - Morfologické obory a cytologie
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000389604900069
    EID SCOPUS84992732420
    DOI10.1371/journal.pone.0165369
    AnotaceDuring pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate blood flow and oxygen transfer in feto-placental capillaries by converting three-dimensional representations of villous and capillary surfaces, reconstructed from confocal laser scanning microscopy, to finite-element meshes, and calculating values of vascular flow resistance and total oxygen transfer. The relationship between the total oxygen transfer rate and the pressure drop through the capillary is shown to be captured across a wide range of pressure drops by physical scaling laws and an upper bound on the oxygen transfer rate. A regression equation is introduced that can be used to estimate the oxygen transfer in a capillary using the vascular resistance. Two techniques for quantifying the effects of statistical variability, experimental uncertainty and pathological placental structure on the calculated properties are then introduced. First, scaling arguments are used to quantify the sensitivity of the model to uncertainties in the geometry and the parameters. Second, the effects of localized dilations in fetal capillaries are investigated using an idealized axisymmetric model, to quantify the possible effect of pathological placental structure on oxygen transfer. The model predicts how, for a fixed pressure drop through a capillary, oxygen transfer is maximized by an optimal width of the dilation. The results could explain the prevalence of fetal hypoxia in cases of delayed villous maturation, a pathology characterized by a lack of the vasculo-syncytial membranes often seen in conjunction with localized capillary dilations.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2017