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Newly developed Ti-Nb-Zr-Ta-Si-Fe biomedical beta titanium alloys with increased strength and enhanced biocompatibility\n

SYSNO ASEP	0466487
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Newly developed Ti-Nb-Zr-Ta-Si-Fe biomedical beta titanium alloys with increased strength and enhanced biocompatibility
Tvůrce(i)	Kopová, Ivana (FGU-C)_RID Stráský, J. (CZ) Harcuba, P. (CZ) Landa, Michal (UT-L)_RID Janeček, M. (CZ) Bačáková, Lucie (FGU-C)_{RID, ORCID}
Zdroj.dok.	Materials Science & Engineering C-Materials for Biological Applications. - : Elsevier - ISSN 0928-4931 Roč. 60, Mar 1 (2016), s. 230-238
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	elastic modulus ; alloy hardening ; cell growth ; osteogenic cell differentiation ; bone implants
Vědní obor RIV	EI - Biotechnologie a bionika
Vědní obor RIV – spolupráce	Ústav termomechaniky - Akustika a kmity
CEP	GAP107/12/1025 GA ČR - Grantová agentura ČR
Institucionální podpora	FGU-C - RVO:67985823 ; UT-L - RVO:61388998
UT WOS	000369204700027
EID SCOPUS	84947944030
DOI	10.1016/j.msec.2015.11.043
Anotace	Beta titanium alloys are promising materials for load-bearing orthopaedic implants due to their excellent corrosion resistance and biocompatibility, low elastic modulus and moderate strength. Metastable beta-Ti alloys can be hardened via precipitation of the alpha phase; however, this has an adverse effect on the elastic modulus. Small amounts of Fe (0-2 wt.%) and Si (0-1 wt.%) were added to Ti-35Nb-7Zr-6Ta (TNZT) biocompatible alloy to increase its strength in beta solution treated condition. Fe and Si additions were shown to cause a significant increase in tensile strength and also in the elastic modulus (from 65 GPa to 85 GPa). However, the elastic modulus of TNZT alloy with Fe and Si additions is still much lower than that of widely used Ti-6A1-4V alloy (115 GPa), and thus closer to that of the bone (10-30 GPa). Si decreases the elongation to failure, whereas Fe increases the uniform elongation thanks to increased work hardening. Primary human osteoblasts cultivated for 21 days on TNZT with 0.5Si + 2Fe (wt.%) reached a significantly higher cell population density and significantly higher collagen I production than cells cultured on the standard Ti-6A1-4V alloy. In conclusion, the Ti-35Nb-7Zr-6Ta-2Fe-0.5Si alloy proves to be the best combination of elastic modulus, strength and also biological properties, which makes it a viable candidate for use in load-bearing implants.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2017

Počet záznamů: 1