Počet záznamů: 1
The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria
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SYSNO ASEP 0465807 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of Her2 and other oncogenes of the PI3K/AKT pathway in mitochondria Tvůrce(i) Rohlenová, Kateřina (BTO-N) ORCID, RID
Neužil, Jiří (BTO-N) RID
Rohlena, Jakub (BTO-N) RID, ORCIDCelkový počet autorů 3 Zdroj.dok. Biological Chemistry. - : Walter de Gruyter - ISSN 1431-6730
Roč. 397, č. 7 (2016), s. 607-615Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova alpha-tocopheryl succinate ; mitochondria ; oxidase subunit-ii ; protein-kinase b Vědní obor RIV EB - Genetika a molekulární biologie CEP ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora BTO-N - RVO:86652036 UT WOS 000377892600004 DOI 10.1515/hsz-2016-0130 Anotace Altered metabolism and resistance to cell death are typical hallmarks of cancer phenotype. Mitochondria are organelles central to cellular metabolism as well as to cell death induction. Hyperactivation of pro-survival and pro-proliferative pathways such as PI3K/AKT leads to cancer initiation, which affects mitochondria. Growing body of evidence indicates that oncogenes such as HER2, EGFR and RAS, as well as the downstream members of the PI3K/AKT signaling pathway, directly regulate mitochondria by translocating to the organelle. Here we discuss evidence of this scenario and consider mechanisms for direct regulation of mitochondrial function. Being in close proximity to mitochondrial bioenergetics machinery as well as to the regulators/executors of programed cell death, oncogenes in mitochondria may be ideally placed to perform this task. This represents a thus far under-explored area, which may be relevant to better understanding of cancer initiation, progression and treatment. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2017
Počet záznamů: 1