Počet záznamů: 1
Quambalarine B, a Secondary Metabolite from Quambalaria cyanescens with Potential Anticancer Properties
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SYSNO ASEP 0465227 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Quambalarine B, a Secondary Metabolite from Quambalaria cyanescens with Potential Anticancer Properties Tvůrce(i) Grobárová, V. (CZ)
Vališ, Karel (MBU-M) ORCID
Talacko, Pavel (MBU-M)
Pavlů, B. (CZ)
Hernychová, Lucie (MBU-M)
Nováková, Jana (MBU-M)
Stodůlková, Eva (MBU-M) ORCID
Flieger, Miroslav (MBU-M) ORCID
Novák, Petr (MBU-M) RID, ORCID
Černý, J. (CZ)Zdroj.dok. Journal of Natural Products. - : American Chemical Society - ISSN 0163-3864
Roč. 79, č. 9 (2016), s. 2304-2314Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova C-MYC ; ENERGY-METABOLISM ; NATURAL-PRODUCTS Vědní obor RIV EE - Mikrobiologie, virologie CEP ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA13-16565S GA ČR - Grantová agentura ČR GP14-21095P GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000384156700021 EID SCOPUS 84988876895 DOI 10.1021/acs.jnatprod.6b00362 Anotace Quambalarine B (QB) is a secondary metabolite produced by the basidiomycete Quambalaria cyanescens with potential anticancer activity. Here we report that QB at low micromolar concentration inhibits proliferation of several model leukemic cell lines (Jurkat, NALM6, and REH), whereas higher concentrations induce cell death. By contrast, the effect of QB on primary leukocytes (peripheral blood mononuclear cells) is significantly milder with lower toxicity and cytostatic activity. Moreover, QB inhibited expression of the C-MYC oncoprotein and mRNA expression of its target genes, LDHA, PKM2, and GLS. Finally, QB blocked the phosphorylation of P70S6K, a downstream effector kinase in mTOR signaling that regulates translation of C-MYC. This observation could explain the molecular mechanism behind the antiproliferative and cytotoxic effects of QB on leukemic cells. Altogether, our results establish QB as a promising molecule in anticancer treatment. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2017
Počet záznamů: 1