Počet záznamů: 1

Design, synthesis and biological activities of new brassinosteroid analogues with a phenyl group in the side chain

SYSNO ASEP	0464462
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Design, synthesis and biological activities of new brassinosteroid analogues with a phenyl group in the side chain
Tvůrce(i)	Kvasnica, Miroslav (UEB-Q)_{RID, ORCID} Oklešťková, Jana (UEB-Q)_{RID, ORCID, SAI} Bazgier, Václav (UEB-Q)_{ORCID, RID} Rárová, L. (CZ) Kořínková, Petra (UEB-Q)_ORCID Mikulík, Jaromír (UEB-Q)_ORCID Buděšínský, Miloš (UOCHB-X)_{RID, ORCID} Béreš, T. (CZ) Berka, K. (CZ) Lu, Q. (BE) Russinova, E. (BE) Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Zdroj.dok.	Organic & Biomolecular Chemistry. - : Royal Society of Chemistry - ISSN 1477-0520 Roč. 14, č. 37 (2016), s. 8691-8701
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	ASYMMETRIC DIHYDROXYLATION ; IMMUNOMODULATORY ACTIVITY ; BRI1
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	LO1204 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	GJ15-08202Y GA ČR - Grantová agentura ČR
	LM2015047 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Institucionální podpora	UEB-Q - RVO:61389030 ; UOCHB-X - RVO:61388963
UT WOS	000384467900010
DOI	10.1039/c6ob01479h
Anotace	We have prepared and studied a series of new brassinosteroid derivatives with a p-substituted phenyl group in the side chain. To obtain the best comparison between molecular docking and biological activities both types of brassinosteroids were synthesized; 6-ketones, 10 examples, and B-lactones, 8 examples. The phenyl group was introduced into the steroid skeleton by Horner-Wadsworth-Emmons. The docking studies were carried out using AutoDock Vina 1.05. Plant biological activities were established using different brassinosteroid bioassays in comparison with natural brassinosteroids. Differences in the production of the plant hormone ethylene were also observed in etiolated pea seedlings after treatment with new brassinosteroids. The most active compounds were lactone 8f and 6-oxo derivatives 8c and 9c, their biological activities were comparable or even better than naturally occurring brassinolide. Finally the cytotoxicity of the new derivatives was studied using human normal and cancer cell lines.
Pracoviště	Ústav experimentální botaniky
Kontakt	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Rok sběru	2017

Počet záznamů: 1