Počet záznamů: 1
Design, synthesis and biological activities of new brassinosteroid analogues with a phenyl group in the side chain
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SYSNO ASEP 0464462 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Design, synthesis and biological activities of new brassinosteroid analogues with a phenyl group in the side chain Tvůrce(i) Kvasnica, Miroslav (UEB-Q) RID, ORCID
Oklešťková, Jana (UEB-Q) RID, ORCID, SAI
Bazgier, Václav (UEB-Q) ORCID, RID
Rárová, L. (CZ)
Kořínková, Petra (UEB-Q) ORCID
Mikulík, Jaromír (UEB-Q) ORCID
Buděšínský, Miloš (UOCHB-X) RID, ORCID
Béreš, T. (CZ)
Berka, K. (CZ)
Lu, Q. (BE)
Russinova, E. (BE)
Strnad, Miroslav (UEB-Q) RID, ORCIDZdroj.dok. Organic & Biomolecular Chemistry. - : Royal Society of Chemistry - ISSN 1477-0520
Roč. 14, č. 37 (2016), s. 8691-8701Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova ASYMMETRIC DIHYDROXYLATION ; IMMUNOMODULATORY ACTIVITY ; BRI1 Vědní obor RIV EB - Genetika a molekulární biologie CEP LO1204 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GJ15-08202Y GA ČR - Grantová agentura ČR LM2015047 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UEB-Q - RVO:61389030 ; UOCHB-X - RVO:61388963 UT WOS 000384467900010 DOI https://doi.org/10.1039/c6ob01479h Anotace We have prepared and studied a series of new brassinosteroid derivatives with a p-substituted phenyl group in the side chain. To obtain the best comparison between molecular docking and biological activities both types of brassinosteroids were synthesized; 6-ketones, 10 examples, and B-lactones, 8 examples. The phenyl group was introduced into the steroid skeleton by Horner-Wadsworth-Emmons. The docking studies were carried out using AutoDock Vina 1.05. Plant biological activities were established using different brassinosteroid bioassays in comparison with natural brassinosteroids. Differences in the production of the plant hormone ethylene were also observed in etiolated pea seedlings after treatment with new brassinosteroids. The most active compounds were lactone 8f and 6-oxo derivatives 8c and 9c, their biological activities were comparable or even better than naturally occurring brassinolide. Finally the cytotoxicity of the new derivatives was studied using human normal and cancer cell lines. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2017
Počet záznamů: 1