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Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring
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SYSNO ASEP 0463864 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring Tvůrce(i) Antvorskov, J.C. (DK)
Josefsen, K. (DK)
Haupt-Jorgensen, M. (DK)
Fundová, Petra (MBU-M) RID
Funda, David P. (MBU-M) RID, ORCID
Buschard, K. (DK)Zdroj.dok. Journal of Diabetes Research. - : Hindawi - ISSN 2314-6745
Roč. 2016, July (2016), s. 3047574Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova ISLET AUTOIMMUNITY ; RISK ; MICE Vědní obor RIV FB - Endokrinologie, diabetologie, metabolizmus, výživa CEP GA15-24487S GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000382686400001 EID SCOPUS 84985918188 DOI 10.1155/2016/3047574 Anotace Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive combinations of gluten-free and standard diet before, during, or after pregnancy. Diabetes incidence in offspring was followed in each group (n = 16-27) for 310 days. Insulitis score and intestinal expression of T-cell transcription factors (RT-QPCR) were evaluated in animals from the different diet groups. Results. If mothers were fed a gluten-free diet only during pregnancy, the development of autoimmune diabetes in offspring was almost completely prevented with an incidence reduction from 62.5% in gluten-consuming mice to 8.3% (P < 0.0001) in the gluten-free group. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2017
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