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Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats
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SYSNO ASEP 0462516 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats Tvůrce(i) Holubová, M. (CZ)
Zemenová, J. (CZ)
Mikulášková, Barbora (FGU-C)
Panajotová, V. (CZ)
Stöhr, J. (CZ)
Haluzík, M. (CZ)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Železná, B. (CZ)
Maletínská, L. (CZ)Zdroj.dok. Journal of Endocrinology. - : BioScientifica - ISSN 0022-0795
Roč. 229, č. 2 (2016), s. 85-96Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova prolactin-releasing peptide ; lipidization ; diet-induced obesity ; ZDF rats ; food intake rat Vědní obor RIV ED - Fyziologie CEP TE01020028 GA TA ČR - Technologická agentura ČR GA15-08679S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000378643100006 EID SCOPUS 84977624840 DOI 10.1530/JOE-15-0519 Anotace Anorexigenic neuropeptides produced and acting in the brain have the potential to decrease food intake and ameliorate obesity, but are ineffective after peripheral application, owing to a limited ability to cross the blood–brain barrier. We have designed lipidized analogs of prolactin-releasing peptide (PrRP), which is involved in energy balance regulation as demonstrated by obesity phenotypes of both Prrp-knockout and Prrp receptor-knockout mice. The aim of this study was to characterize the subchronic effect of a palmitoylated PrRP analog in two rat models of obesity and diabetes: diet-induced obese Sprague–Dawley rats and leptin receptor-deficient Zucker diabetic (ZDF) rats. In the rats with diet-induced obesity (DIO), a two-week intraperitoneal treatment with palmitoylated PrRP lowered food intake by 24% and body weight by 8%. This treatment also improved glucose tolerance and tended to decrease leptin levels and adipose tissue masses in a dose-dependent manner. In contrast, in ZDF rats, the same treatment with palmitoylated PrRP lowered food intake but did not significantly affect body weight or glucose tolerance, probably in consequence of severe leptin resistance due to a nonfunctional leptin receptor. Our data indicate a good efficacy of lipidized PrRP in DIO rats. Thus, the strong anorexigenic, body weight-reducing, and glucose tolerance-improving effects make palmitoylated PrRP an attractive candidate for anti-obesity treatment. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2017
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