Počet záznamů: 1
The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility
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SYSNO ASEP 0461775 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility Tvůrce(i) Sillam-Dusses, D. (FR)
Hanus, Robert (UOCHB-X) RID, ORCID
Poulsen, M. (DK)
Roy, V. (FR)
Favier, M. (FR)
Vasseur-Cognet, M. (FR)Číslo článku 160080 Zdroj.dok. Open Biology. - : Royal Society Publishing
Roč. 6, č. 5 (2016)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova reproduction ; phenotypic plasticity ; carbohydrate-responsive element-binding protein ; transcription factor ; social insects ; lipogenesis Vědní obor RIV EB - Genetika a molekulární biologie CEP GA14-12774S GA ČR - Grantová agentura ČR Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000376964600007 EID SCOPUS 84978198617 DOI 10.1098/rsob.160080 Anotace Termites are among the few animals that themselves can digest the most abundant organic polymer, cellulose, into glucose. In mice and Drosophila, glucose can activate genes via the transcription factor carbohydrate-responsive element-binding protein (ChREBP) to induce glucose utilization and de novo lipogenesis. Here, we identify a termite orthologue of ChREBP and its downstream lipogenic targets, including acetyl-CoA carboxylase and fatty acid synthase. We show that all of these genes, including ChREBP, are upregulated in mature queens compared with kings, sterile workers and soldiers in eight different termite species. ChREBP is expressed in several tissues, including ovaries and fat bodies, and increases in expression in totipotent workers during their differentiation into neotenic mature queens. We further show that ChREBP is regulated by a carbohydrate diet in termite queens. Suppression of the lipogenic pathway by a pharmacological agent in queens elicits the same behavioural alterations in sterile workers as observed in queenless colonies, supporting that the ChREBP pathway partakes in the biosynthesis of semiochemicals that convey the signal of the presence of a fertile queen. Our results highlight ChREBP as a likely key factor for the regulation and signalling of queen fertility. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2017 Elektronická adresa http://rsob.royalsocietypublishing.org/content/6/5/160080
Počet záznamů: 1