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Biodegradable multiblock polymers based on N-(2-hydroxypropyl)methacrylamide designed as drug carriers for tumor-targeted delivery
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SYSNO ASEP 0461622 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biodegradable multiblock polymers based on N-(2-hydroxypropyl)methacrylamide designed as drug carriers for tumor-targeted delivery Tvůrce(i) Mužíková, Gabriela (UMCH-V) RID
Pola, Robert (UMCH-V) RID, ORCID
Laga, Richard (UMCH-V) RID, ORCID
Pechar, Michal (UMCH-V) RID, ORCIDZdroj.dok. Macromolecular Chemistry and Physics. - : Wiley - ISSN 1022-1352
Roč. 217, č. 15 (2016), s. 1690-1703Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova biodegradable polymers ; click chemistry ; drug delivery systems Vědní obor RIV CD - Makromolekulární chemie CEP GA14-12742S GA ČR - Grantová agentura ČR GA16-17207S GA ČR - Grantová agentura ČR LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000382964300005 EID SCOPUS 84977573621 DOI 10.1002/macp.201600097 Anotace Biodegradable multiblock (co)polymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) for drug delivery applications are prepared by azide–alkyne polycycloaddition of end-functionalized precursors synthesized by reversible addition–fragmentation chain transfer polymerization. Copper-catalyzed polyaddition of the heterotelechelic polymer precursors containing azide and alkyne groups provides (A)x-type multiblock (co)polymers. For the first time, thermally degradable multiblock polymers of (AB)x-type are prepared via polyaddition of homotelechelic polymer diazides with azo-compounds containing two alkyne groups. A novel type of HPMA-based multiblock (co)polymers undergoing the pH-dependent hydrolysis is reported. The (co)polymers containing the Asp-Pro-Lys sequence are relatively stable in an aqueous buffer at physiological pH 7.4; however, they undergo rapid hydrolysis at pH 5.0 corresponding to the pH in lysosomes. The multiblock polymer containing the Gly-Phe-Leu-Lys linkage is degraded in the presence of the lysosomal protease cathepsin B. Thermal degradation of the (AB)x-type multiblock polymers proceeds even at 37 °C, yielding a mixture of polymer degradation products with molecular weights below the renal threshold. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2017
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