Počet záznamů: 1

Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system

SYSNO ASEP	0461572
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system
Tvůrce(i)	Krejčí, Eliška (FGU-C)_RID Peševski, Živorad (FGU-C) Naňka, O. (CZ) Sedmera, David (FGU-C)_{RID, ORCID, SAI}
Zdroj.dok.	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 65, č. 3 (2016), s. 425-435
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	CZ - Česká republika
Klíč. slova	chick embryo ; vasculogenesis ; FGF2 ; FGFR1 ; myocyte proliferation ; conotruncal banding ; SU5402
Vědní obor RIV	FA - Kardiovaskulární nemoci vč. kardiochirurgie
CEP	GAP302/11/1308 GA ČR - Grantová agentura ČR
	GA16-02972S GA ČR - Grantová agentura ČR
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000382115700006
EID SCOPUS	84979771512
Anotace	Fibroblast growth factor (FGF) signaling plays an important role during embryonic induction and patterning, as well as in modulating proliferative and hypertrophic growth in fetal and adult organs. Hemodynamically induced stretching is a powerful physiological stimulus for embryonic myocyte proliferation. The aim of this study was to assess the effect of FGF2 signaling on growth and vascularization of chick embryonic ventricular wall and its involvement in transmission of mechanical stretchinduced signaling to myocyte growth in vivo. Myocyte proliferation was significantly higher at the 48 h sampling interval in pressure-overloaded hearts. Neither Western blotting, nor immunohistochemistry performed on serial paraffin sections revealed any changes in the amount of myocardial FGF2 at that time point. ELISA showed a significant increase of FGF2 in the serum. Increased amount of FGF2 mRNA in the heart was confirmed by real time PCR. Blocking of FGF signaling by SU5402 led to decreased myocyte proliferation, hemorrhages in the areas of developing vasculature in epicardium and digit tips. FGF2 synthesis is increased in embryonic ventricular cardiomyocytes in response to increased stretch due to pressure overload. Inhibition of FGF signaling impacts also vasculogenesis, pointing to partial functional redundancy in paracrine control of cell proliferation in the developing heart.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2017

Počet záznamů: 1