Počet záznamů: 1
Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs
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SYSNO ASEP 0460675 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs Tvůrce(i) Dumková, J. (CZ)
Vrlíková, Lucie (UZFG-Y) ORCID
Večeřa, Zbyněk (UIACH-O) RID
Putnová, Barbora (UZFG-Y)
Dočekal, Bohumil (UIACH-O) RID, ORCID
Mikuška, Pavel (UIACH-O) RID, ORCID
Fictum, P. (CZ)
Hampl, A. (CZ)
Buchtová, Marcela (UZFG-Y) RID, ORCIDZdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 17, č. 6 (2016), s. 874-893Poč.str. 20 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova nanoparticles ; cadmium oxide ; electron microscopy Vědní obor RIV EB - Genetika a molekulární biologie Vědní obor RIV – spolupráce Ústav analytické chemie - Analytická chemie, separace CEP GAP503/11/2315 GA ČR - Grantová agentura ČR GBP503/12/G147 GA ČR - Grantová agentura ČR Institucionální podpora UZFG-Y - RVO:67985904 ; UIACH-O - RVO:68081715 UT WOS 000378799300088 EID SCOPUS 84971668007 DOI 10.3390/ijms17060874 Anotace The increasing amount of heavy metals used in manufacturing equivalently increases hazards of environmental pollution by industrial products such as cadmium oxide (CdO) nanoparticles. Here, we aimed to unravel the CdO nanoparticle destiny upon their entry into lungs by inhalations, with the main focus on the ultrastructural changes that the nanoparticles may cause to tissues of the primary and secondary target organs. We indeed found the CdO nanoparticles to be transported from the lungs into secondary target organs by blood. In lungs, inhaled CdO nanoparticles caused significant alterations in parenchyma tissue including hyperemia, enlarged pulmonary septa, congested capillaries, alveolar emphysema and small areas of atelectasis. Nanoparticles were observed in the cytoplasm of cells lining bronchioles, in the alveolar spaces as well as inside the membranous pneumocytes and in phagosomes of lung macrophages. Nanoparticles even penetrated through the membrane into some organelles including mitochondria and they also accumulated in the cytoplasmic vesicles. In livers, inhalation caused periportal inflammation and local hepatic necrosis. Only minor changes such as diffusely thickened filtration membrane with intramembranous electron dense deposits were observed in kidney. Taken together, inhaled CdO nanoparticles not only accumulated in lungs but they were also transported to other organs causing serious damage at tissue as well as cellular level. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2017
Počet záznamů: 1