Počet záznamů: 1
Polycaprolactone foam functionalized with chitosan microparticles – a suitable scaffold for cartilage regeneration.
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SYSNO ASEP 0459654 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polycaprolactone foam functionalized with chitosan microparticles – a suitable scaffold for cartilage regeneration. Tvůrce(i) Filová, Eva (UEM-P) RID, ORCID
Jakubcová, B. (CZ)
Danilová, I. (CZ)
Kuželová Košťáková, E. (CZ)
Jarošíková, T. (CZ)
Chernyavskiy, Oleksandr (FGU-C)
Hejda, J. (CZ)
Handl, M. (CZ)
Beznoska, J. (CZ)
Nečas, A. (CZ)
Rosina, J. (CZ)
Amler, Evžen (UEM-P) RIDZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 65, č. 1 (2016), s. 121-131Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova poly-epsilon-caprolactone ; chitosan ; cartilage regeneration ; foam Vědní obor RIV FI - Traumatologie, ortopedie Institucionální podpora UEM-P - RVO:68378041 ; FGU-C - RVO:67985823 UT WOS 000377529800013 EID SCOPUS 84963818690 Anotace For biodegradable porous scaffolds to have a potential application in cartilage regeneration, they should enable cell growth and differentiation and should have adequate mechanical properties. In this study, our aim was to prepare biocompatible scaffolds with improved biomechanical properties. To this end, we have developed foam scaffolds from poly-epsilon-caprolactone (PCL) with incorporated chitosan microparticles. The scaffolds were prepared by a salt leaching technique from either 10 or 15 wt% PCL solutions containing 0, 10 and 20 wt% chitosan microparticles, where the same amount and size of NaCl was used as a porogen in all the cases. PCL scaffolds without and with low amounts of chitosan (0 and 10 wt% chitosan) showed higher DNA content than scaffolds with high amounts of chitosan during a 22-day experiment. 10 wt% PCL with 10 and 20 wt% chitosan showed significantly increased viscoelastic properties compared to 15 wt% PCL scaffolds with 0 and 10 wt% chitosan. Thus, 10 wt% PCL scaffolds with 0 wt% and 10 wt% chitosan are potential scaffolds for cartilage regeneration. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2017
Počet záznamů: 1