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From Functionalized Nanostructures Towards Engineered Macrostructures
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SYSNO ASEP 0459255 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Stem Cell Treatment in Amyotrophic Lateral Sclerosis Tvůrce(i) Forostyak, Serhiy (UEM-P) RID, ORCID
Syková, Eva (UEM-P) RIDZdroj.dok. From Functionalized Nanostructures Towards Engineered Macrostructures. - Jindřichův Hradec : Epika, 2015 / Caruana Carmel ; Horník Jakub - ISBN 978-80-88113-20-1 Rozsah stran s. 61-73 Poč.str. 13 s. Poč.str.knihy 176 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova amyotrophic lateral sclerosis ; neurodegenerative disorders ; mesenchymal stromal cells Vědní obor RIV FP - Ostatní lékařské obory CEP LO1309 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UEM-P - RVO:68378041 Anotace Amyotrophic lateral sclerosis (ALS) is a largely sporadic progressive neurodegenerative disease affecting upper and lower motor neurons (MNs) and specific etiology that is not completely understood. Up to now, there is no clinically relevant treatment available for ALS. The novel therapeutic strategies should aim at neuroprotection, stimulation of intrinsic neurogenesis and replacement of affected neural cells. These could be achieved by application of powerful modern therapeutic methods such as gene therapy, transplantation of different types of engineered and non-engineered stem cells. Cell-based therapies could facilitate either restoration/substitution or the preservation of MNs. Special attention has been paid to treatment with autologous stem cells, as the most promising approach to the treatment of ALS patients. This review summarises the progress made in translating to the patients' bedside the results achieved from in vivo preclinical studies. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2017
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