Počet záznamů: 1
Mouse Incisor Stem Cell Niche and Myb Transcription Factors
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SYSNO ASEP 0457856 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mouse Incisor Stem Cell Niche and Myb Transcription Factors Tvůrce(i) Švandová, Eva (UZFG-Y) RID, ORCID
Veselá, Barbora (UZFG-Y) RID
Šmarda, J. (CZ)
Hampl, A. (CZ)
Radlanski, R.J. (DE)
Matalová, Eva (UZFG-Y) RIDZdroj.dok. Anatomia Histologia Embryologia-Journal of Veterinary Medicine Series C - ISSN 0340-2096
Roč. 44, č. 5 (2015), s. 338-344Poč.str. 7 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova c-Myb ; stem cell niches Vědní obor RIV EA - Morfologické obory a cytologie CEP GAP304/11/1418 GA ČR - Grantová agentura ČR GCP302/12/J059 GA ČR - Grantová agentura ČR Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000360837500004 EID SCOPUS 84940874662 DOI 10.1111/ahe.12145 Anotace Dental hard tissues are formed particularly by odontoblasts (dentin) and ameloblasts (enamel). Whereas the reparation of dentin is often observed, enamel does not regenerate in most species. However, in mouse incisor, a population of somatic stem cells in the cervical loop is responsible for the incisor regeneration. Understanding of the specificities of these cells is therefore of an interest in basic research as well as regenerative therapies. The Myb transcription factors are involved in essential cellular processes. B-Myb is often linked to the stem cell phenotype, and c-Myb expression marks undifferentiated and proliferating cells such as the stem cells. In the presented study, temporo-spatial expression of B-Myb and c-Myb proteins was correlated with localisation of putative somatic stem cells in the mouse incisor cervical loop by immunohistochemistry. B-Myb expression was localised mostly in the zone of transit-amplifying cells, and c-Myb was found in the inner enamel epithelium, the surrounding mesenchyme and in differentiated cells. Taken together, neither B-Myb nor c-Myb was exclusively present or abundant in the area of the incisor stem cell niche. Their distribution, however, supports recently reported novel functions of c-Myb in differentiation of hard tissue cells. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2016
Počet záznamů: 1